Family of nuclear peroxisome proliferator-activated receptors (PPARS): biological role in metabolic adaptation part III. PPARγ and its role in autophagy, inflammation, carcinogenesis and reproductive system upon the exposure to xenobiotics (report 2)
Journal Title: Український журнал сучасних проблем токсикології - Year 2017, Vol 77, Issue 1
Abstract
Objective. Analysis and summary of the current concept of biological and physiological role of nuclear peroxisome pro-liferator-activated receptor gamma (PPARγ) in the development and functioning of reproductive system, in regulation of autophagy, inflammation, and carcinogenesis. Materials and Methods. Analytical review of scientific publications was performed using abstract databases of scientific libraries and text database of methodological and biological publications PubMed. Results. Physiological role of PPARγ in the development and functioning of reproductive system organs was established; its important role in energy supply for ovulation processes, oestrogen secretion, functioning of placenta, claustrophobia, embriogenesis was determined. Its regulating role in the processes of autophagy, inflammation and carcinogenesis was established. Pro-inflammatory, antioxidative, antiproliferative effects, inhibition of tumour growth and metastasis of cancer cells upon PPARγ activation were found. Metabolic and endocrine disrupter effects ofxenobiotics due to PPARγ dysfunction were noticed. Use of PPARγ as a therapeutic target upon management of reproductive disorders, inflammatory processes and cancer was justified.
Authors and Affiliations
G. M. Balan, N. M. Bubalo, V. O. Bubalo, P. G. Zhminko, V. A. Babych
Keywords
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