Fatty acid composition in cerebral cortex, hippocampus and cerebellum in adult rats receiving salmon oil for 6 months
Journal Title: Journal of Pre-Clinical and Clinical Research - Year 2014, Vol 8, Issue 1
Abstract
[b]Introduction.[/b] Polyunsaturated fatty acids (PUFA) play an important role in the functioning of the brain, particularly in childhood and old age. The diet of pregnant mothers as well as very young children, affects the composition of fatty acids in childrens’ brains and suggests the question of whether a diet enriched in n-3 PUFA throughout adult life may result in elevated levels of PUFA n-3 in individual brain regions, and thus delay the aging process. [b]Objective.[/b] The purpose of this research was to establish the fatty acid composition in the cerebral cortex, hippocampus and cerebellum in adult rats receiving for 6 months salmon oil, which is a rich source of n-3 fatty acid. [b]Materials and method.[/b] 6-week-old rats were acclimatized for 2 weeks and then assigned into 2 groups (n=10): control and fish oil supplemented. Both control and supplemented animals were fed a semi-synthetic, isoenergetic diet that varied only in fat composition. The brain fatty acids profile was determined by gas-chromatography analysis. [b]Results. [/b]Rats fed the supplemented diet showed an increased level of 22:6n-3 and a decreased level of 20:4n-6 and C22:5n-6 in all brain regions when compared to the control group. Furthermore, there was an increase of all monounsaturated fatty acids (MUFA) only in the hippocampus of supplemented rats when compared to the control group. Saturated fatty acids (SFA) content was only slightly modified in the administered diets. [b]Conclusions[/b]. A diet rich fish oil can restore an adequate level of fatty acid in the aging brain.
Authors and Affiliations
Maciej Firląg, Piotr Ostaszewski, Bożena Balasinska
Keywords
Related Articles
- EP ID EP58513
- DOI -
- Views 118
- Downloads 0
Giant osteoma of the paranasal sinuses and right orbit in a patient with trauma history in CT imaging.
This report presents a case of giant osteoma of the right frontal and ethmoidal sinus, nasolacrimal duct and orbit in a patient with history of trauma, investigated using the computed tomography technique. The epidemiolo...
Effect of IEM 1460 – a selective antagonist of GluR2-lacking AMPA receptors – on the action of conventional antiepileptic drugs against maximal electroshock in mice
The objective of the study was to determine the effect of combined treatment with IEM-1460 (a selective GluR2-lacking, Ca[sup] 2+[/sup] permeable AMPA receptors) and conventional antiepileptic drugs: CBZ (carbamazepine)...
Organochlorine pesticide residues in breast milk in Armenia
The study evaluates organochlorine pesticide (OCP) exposure and the possible relationship with adverse birth outcomes through analysis of breast milk samples from a rural Armenian population in 1993-2000. 266 samples wer...
Lethal acute liver failure in a 60 y/o female patient with AILD III (Ann Arbor) T-cell lymphoma in remission state – Case report
Acute liver failure (ALF) is a rare condition in which liver function deteriorates suddenly, leading to encelopathy and coagulopathy in patients previously unaffected with hepatic cirrhosis. The case is presented of a 60...
Foot metastasis as a first clinical manifestation of rectal carcinoma
The incidence of colorectal carcinoma in the European population is high. The present paper describes the case of a farmer whose first symptom of rectal carcinoma was a metastatic tumour to the foot bones. Histopatholog...