Follicular-patterned thyroid lesions
Journal Title: Turkish Journal of Pathology - Year 2009, Vol 25, Issue 1
Abstract
Aim: Our aim is to determine the minimal cytopathologic criteria needed to make differential diagnosis in follicular-patterned lesions of the thyroid gland. Materials and Methods: We reviewed 56 fine needle aspiration cytology specimens which were reported as “suspicious for follicular-patterned lesions of thyroid” between years 2001 and 2005 in our hospital and their histological slides. Parameters for cytopathologic assesment are cellularity, colloid formation, multilayered rosette formation, follicular cell rings, monolayered sheets, intact follicles, hyperplastic papillae, hyaline stromal fragments, intranuclear inclusions, nuclear grooves, angulated nuclei, nucleoli, cerebriform nuclei, nuclear size, macrophages, flame cells and Hurthle cells. Statistical analysis was performed using χ2 and Fisher's-exact tests and Kolmogorov-Simirnov test. Results: Four cytopathologic features–cerebriform nuclei, angulated nuclei, nuclear grooves and intranuclear inclusion- were constantly observed in the follicular variant of papillary carcinoma (p< 0.05). Diluted colloid, monolayered sheet, nuclear size, macrophage and nucleoli were frequently seen in nodular hyperplasia (p< 0.05). The nuclear size was the sole differential cytopathologic criteria between follicular adenoma and follicular carcinoma (p<0.05). Conclusion: Detailed cytopathologic examination was found to be important in differentiating follicular variant of papillary carcinoma from nodular hyperplasia. On the other hand, none of the cytopathologic findings were sufficient to distinguish follicular adenoma from follicular carcinoma. Therefore, cytopathologists should report such lesions as “follicular neoplasms”.
Authors and Affiliations
F. Fulya KÖYBAŞIOĞLU, Özgür İlhan ÇELİK, Nuray Güneri TOSUNOĞLU, Binnur ÖNAL, Ayşegül ADABAĞ
Keywords
Related Articles
- EP ID EP84476
- DOI 10.5146/tjpath.2009.00959
- Views 133
- Downloads 0
Bioprotective Efficacy of Erucin Against 7,12-Dimethylbenz(α)anthracene-Induced Microstructural Changes in Male Wistar Rats
Objective: Environmental pollutants are responsible for inducing a number of biochemical and physical changes in the various organs of an organism. The most potent pollutants is7,12-dimethylbenz(α)anthracene (DMBA) (a ge...
Jeneralize morfea-liken skleroatrofik birlikteliği
Lokalize fibrozan hastalıklar, genellikle çocukluk çağında başlayan, nadir görülen bir hastalık spektrumudur. Morfea ve liken skleroatrofik, bu hastalık spektrumunda yer alan genellikle dermis, subkütan yağ dokusu ve yum...
Immunohistochemical Analysis of the Extrinsic Apoptosis Process in the Non-Neoplastic and Neoplastic Prostate
Objective: Deviations in the apoptotic process have been demonstrated in prostate carcinogenesis. We aimed to evaluate especially the process of extrinsic apoptosis in the spectrum of neoplastic lesions of the prostate e...
Hamdi Suat ve Hulusi Behçet: Tıp Tarihimizden Dokunaklı bir Öğrenci - Hoca İlişkisi
Bu makalede, Türk tıp tarihinin iki seçkin siması olan Hamdi Suat Aknar (1873-1936) ve Hulusi Behçet (1889-1948) arasındaki hoca-öğrenci ilişkisi ele alınmıştır. Türkiye'de çağdaş patolojinin öncüsü olan Hamdi Suat Aknar...
Tumor Budding in Colorectal Carcinomas.
Objective: In colorectal carcinomas, tumor budding has been defined as the presence of isolated single tumor cells or small cell clusters in the stroma at the invasive tumor margin. In this study, the relationshi...