FORMULATING TASTE-MASKED ORALLY DISINTEGRATING TABLETS OF A BITTER DRUG IBUPROFEN
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 11
Abstract
This study is aimed at formulating taste-masked orally disintegrating tablets of a bitter drug i.e., Ibuprofen. Taste masking was carried out by fluid bed coating of extruded and spheronized pellets comprising of Ibuprofen, microcrystalline cellulose and lactose. Two marketed taste-masking systems, namely Eudragit EPO and Opadry tm were evaluated. For the formulation of orally disintegrating tablets a range of excipients such as super disintegrants, diluents, sweeteners and flavours were evaluated and a prototype formulation was selected. This prototype formulation had Eudragit EPO coated taste masked pellets and selected excipients. Its disintegration time was found to be about 8 seconds. Tablets were evaluated for their taste, disintegration time, hardness, friability, water uptake and drug release profile. It was concluded from this study that water insoluble, water permeable polymer system like Eudragit EPO can effectively taste mask bitter drugs without unduly affecting their drug release profile. As per objective of the work, the formulation was found to have a disintegration time of less than 30 seconds (about 8 seconds), had good mouth feel and organoleptic properties. With Eudragit EPO the bitterness and burning sensation of drug was significantly masked at low coating levels (15 %) without affecting the Ibuprofen release.
Authors and Affiliations
Naresh Kothapally , Sandeep Devareddy
Keywords
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- EP ID EP99100
- DOI 10.7897/2230-8407.041117
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