FORMULATION AND E VALUATION OF FAMOTIDINE FAST DISSOLVING TABLETS BY DIRECT COMPRESSION METHOD
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 5
Abstract
Fast dissolving tablets were highly accepted drug delivery system. Fast dissolving tablets were dissolved/ disintegrated in the mouth within a matter of few seconds without need of water. The aim of the present study was to prepare and evaluate fast dissolving tablets of Famotidine using a combined approach of complexing agent and super disintegrant.Fast dissolving tablets were prepared by direct compression technique .The prepared tablets were dried under oven for evaporate the complexing agent and drug release. The tablets were evaluated for weight variation, friability, hardness, in vitro disintegration time, in vitro drug release profile .And there is no interactions find in Ftir studies .The obtained results showed that weight variation. Good hardness, acceptable friability. All the formulation disintegrated within 10-60 secondsand the drug release shows 99.3%. The formulation containing complexing agent and superdisintegrants showed better performance in disintegration and drug release profile.
Authors and Affiliations
B. Venkateswarlu, B. Pragati Kumar, Debjit Bowmik
Keywords
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