Formulation and Evaluation of Medicated Nail Patches for the Treatment of Onychomycosis
Journal Title: International Journal of Pharmaceutical Science Invention - Year 2018, Vol 7, Issue 4
Abstract
The oral therapies encounter side effects and topical therapies for nail diseases are limited by poor permeability of nail plate. An optimal penetration enhancer would improve drug delivery through nail plate facilitating new possibilities for treating neighboring target sites if the systemic circulation is reached. The present investigation aims to formulate and evaluate of medicated nail patches for the treatment of diseases like Onychomycosis (fungal infection of nail) and psoriasis, Yellow nail syndrome, Paronychia and many others. The objective of study to explore the difficulties in penetration of drug across nail patches and to enhance bioavailability of antifungal drugs. Nail drug delivery system is used to reduce such a hazardous systemic effects and provides longer contact time at a site of action. Many formulation of clotrimazole were prepared by using optimized formula which shows better diffusion and permeation. These are evaluated for various parameters including in-vitro release (Diffusion) studies in 7.4 pH phosphate buffers. Effects of varying concentration of various excipients were studied. The evaluation of that patches is carried out by drug excipient interactions subjecting to FTIR Spectral analysis, in-vitro diffusion studies, drug content analysis, NDDS is used to achieve maximum therapeutic effect along with improve patient’s compliance.
Authors and Affiliations
Gaddime Sonali B. , Nagoba S. N. , Pattewar Shraddha G. , Wadulkar R. D. , Thonte S. S.
Keywords
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