FORMULATION AND EVALUATION OF NASAL IN SITU GEL OF RIZATRIPTAN BENZOATEFORMULATION AND EVALUATION OF NASAL IN SITU GEL OF RIZATRIPTAN BENZOATE
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2017, Vol 6, Issue 2
Abstract
In situ gel drug delivery systems are in elucidation form prior to supervision but once administered, endure gelation in situ, to form a gel. In the current revise nasal in situ gel of rizatriptan Benzoate was primed for the cure of nasal infections to give sustained release of drug and to attain site specific action. Carbopol was use as a pH triggered polymer Different formulations were prepared by varying the concentrations of Carbopo with Hydroxylpropyl Methylcellulose (HPMC). These formulations were evaluated for parameters like drug excipient compatibility, pH, drug content, gelation temperature, viscosity, in vitro drug release, mucoadhesion, ex vivo permeation and stability studies. FTIR study exposed that there was no interface between drug and polymer. pH of all the formulations were initiate to be in the vary of 5.4-6.2 and the drug substance for all the prepared formulations was initiate to be in the assortment of 94%-99%. The results of in vitro drug release and mucoadhesive strength indicated that the optimized formulation F5 and is the most successful formulations of the study, exhibited a sustained drug release of in 87.7% in 7 hours. mucoadhesive strength of 2024.64 and 3267.76 dyne/cm2. From the results it is fulfilled that rizatriptan Benzoate nasal in situ gel produce extended and site specific drug delivery.
Authors and Affiliations
Piyush Agarwal*| Bhupal Nobels College of Pharmaceutical Sciences, Udaipur, Rajasthan, India, Amit Kumar| Dept of Pharmacy, Jodhpur National University, Jodhpur, Rajasthan, India, Y. S. Tanwar| Bhupal Nobels College of Pharmaceutical Sciences, Udaipur, Rajasthan, India, Shailendra Sharma| Jodhpur Institute of Pharmacy, Jodhpur, Rajasthan, India
Keywords
Related Articles
- EP ID EP3833
- DOI -
- Views 433
- Downloads 24
DESIGN AND DEVELOPMENT OF EUDRAGIT COATED CHITOSAN MICROSPHERES FOR COLON TARGETED DELIVERY
Oral route is the most convenient and preferred route but other routes for CDDS may be used. Rectal administration offers the shortest route for targeting drugs to the colon. However, reaching the proximal part of colo...
CHARACTERISATION AND OPTIMISATION OF BIOSURFACTANT PRODUCED BY PSEUDOMONAS FLUORESCENS FROM OIL CONTAMINATED SOIL
The biosurfactant producing strain Pseudomonas fluorescens was isolated from Dharmapuri District, Tamil Nadu. India. The biosurfactant produced by Pseudomonas fluorescens was able to reduce the surface tension of media...
EFFECT OF POSTMENOPAUSAL STATUS ON SERUM LIPIDS PROFILE AND URIC ACID IN SUDANESE FEMALES FROM THE GENERAL POPULATION
BACKGROUND: Previous data suggest possible effects of postmenopause on serum lipids profile and uric acid which are established risk factors for cardiovascular system. AIM: to evaluate the changes that may occur on ser...
Formulation and Evaluation of Pluronic lecithin organogel of Flurbiprofen
The aim of the present work was to generate an index to predict topical ef®ciency of a series of nonsteroidal anti-in¯ammatory drugs Organogel, a viscoelastic system, can be regarded as a semi-solid preparation which has...
PHENYTOIN INDUCED TOXIC EPIDERMAL NECROLYSIS; A CASE REPORT
Several drugs are at high risk of causing Toxic Epidermal Necrolysis (TEN) including Anti-convulsants such as phenytoin, carbamazepine and phenobarbital. Other drugs include antimicrobials like sulfonamides followed by N...