FORMULATION AND EVALUATION OF VENLAFAXINE HYDROCHLORIDE BUCCAL PATCHES
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 3
Abstract
The present study involves the formulation and evaluation of buccal patches of venlafaxine hydrochloride using sodium alginate with various hydrophilic polymers like carbopol 934 P, carboxymethyl cellulose and hydroxypropylmethylcellulose K4M in various proportions and combinations were fabricated by solvent casting technique. Venlafaxine hydrochloride an antidepressant drug to circumvent the first pass metabolism. Buccal route is excellent for the systemic delivery, there by rendering great bioavailability. A significant reduction in dose and dosing frequency can be achieved, thereby reducing dose dependent side effects, patient compliance and prolonging duration of action. Various physicomechanical parameters like weight variation, thickness, folding endurance, drug content, moisture content, moisture absorption, and various ex vivo mucoadhesion parameters like mucoadhesive strength, force of adhesion and bond strength were evaluated. An in vitro drug release study was designed, and it was carried out using commercial semipermeable membrane. All these fabricated patches were sustained for 10 hrs and obeyed first-order release kinetics. Ex vivo drug permeation study was also performed using porcine buccal mucosa, and various drug permeation parameters like flux and lag time were determined.
Authors and Affiliations
Senthil Adimoolam , Pratik Chauhan , Yakinkumar Siroya , Falguniben Patel , Byruppa Vantoor
Keywords
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