FORMULATION AND IN-VITRO EVALUATION OF ORNIDAZOLE GASTRORETENTIVE TABLETS BY USING LOW DENSITY SWELLABLE POLYMERS
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 5
Abstract
Gastro retentive drug delivery systems have shown to be of better significance in controlling release rate for drugs having site specific absorption. The present study was an attempt to develop floating tablets of ornidazole which on oral administration prolongs its gastric residence time there by increasing bioavailability. Ornidazole an oral antiprotozoal having narrow absorption window in the upper and lower part of gastrointestinal tract, floating matrix tablet using gas generating agent sodium bicarbonate and hydrophilic polymer Hydroxy propyl methyl cellulose by wet granulation technique. Preformulation studies were carried out to optimize the required quantity for HPMC K4M(10%), Eudragit(8%) was used. formulations were prepared using either HPMC k50, HPMC k100, HPMC k4, Xanthan gum, Ethyl cellulose with carbopol 934P. For F1 to F8 formulation HPMC concentration was increased to control the release of drug from the dosage form and for F11 formulation Eudragit concentration was increased to obtain viscosity. Fourier transform Infrared spectroscopy confirmed the absence of any drug/polymers/excipients interactions. F11 Formulations showed in-vitro buoyancy 9 hrs. The concentration of HPMC K4 was increased to control the release of drug from the dosage form for F11 , the concentration was increased for Eudragit to increase the binding nature . The cumulative % drug release of F11 formulation was found to be Ornidazole (92.8%) at the end of 9th hr. The formulation containing HPMC k4m and Eudragit showed better results compared to other formulated batches. Further Stability studies studies can be performed to ensure the efficacy of the formulated floating tabets.
Authors and Affiliations
Abeda Aqther, B. Pragati kumar, Peer Basha
Keywords
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