Sustained release drug delivery system: review
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2015, Vol 3, Issue 3
Abstract
Sustained release dosage forms are designed to release a drug at a predetermined rate by maintaining a constant drug level for a specific period of time with minimum side effects. The basic rationale of sustained release drug delivery system optimizes the biopharmaceutical, pharmacokinetic and pharmacodynamic properties of a drug in such a way that its utility is maximized, side-effects are reduced and cure of the disease is achieved. There are several advantages of sustained release drug delivery over conventional dosage forms like improved patient compliance due to less frequent drug administration, reduction of fluctuation in steady-state drug levels, maximum utilization of the drug, increased safety margin of potent drug, reduction in healthcare costs through improved therapy and shorter treatment period. Drug release through matrix system is determined by Water penetration, Polymer swelling, Drug dissolution, Drug diffusion, Matrix erosion have been utilized as formulation approaches. The present article contains brief review on various formulation approaches for Sustained release drug delivery system.
Authors and Affiliations
Kube Rahul S. , Kadam V. S, Shendarkar G. R, Jadhav S. B, Bharkad
Keywords
Related Articles
- EP ID EP33309
- DOI -
- Views 291
- Downloads 0
Simultaneous estimation and method validation of Terbutaline sulfate and Guaifenesin in liquid dosage form by RP-HPLC
The present study aimed to develop a sustained release Pregabalin microcapsules by using chitosan, ethyl cellulose and sodium alginate. The techniques employed for the preparation of microcapsules are phase separation...
Evaluation of in-vitro anthelminthic activity of leaf and bark aqueous extracts of Santalum album linn
Santalum album Linn is the most significant genus in the family Santalaceae, which is commonly known as Sri gandham in India. This study evaluates anthelmintic activity of Aqueous leaf and bark extracts of Santalum alb...
Study of effect of drying on the colour of Artemisia dracunculus L. leaves in different treatments of drying
The affection of different treatment of drying of Artemisia dracunculus L. studied. Artemisia dracunculus L. leaves dried base on shadow, sun, oven (70◦C, 100◦C) and microwave methods. In different time intervals, samp...
Highly selective, sensitive and precise Bioanalytical method for the estimation of amoxicillin and clavulanic acid in nano gram range in Albino rat's plasma
LC-MS/MS method for the determination of amoxicillin and clavulanic acid in Albino rat's plasma was developed and validated according to currently accepted FDA guidelines of Bioanalytical method validation. The retenti...
Design and development of buccal tablets of Metoprolol tartarate by core in cup technology
A precise, simple, cost effective, accurate Ultra violet spectrophotometric method has been developed for the determination of Edoxaban Tosylate Monohydrate (EDTM) in the Pharmaceutical dosage form. EDTM shows highest...