FORMULATION DEVELOPMENT AND ASSESSMENT OF CONTROLLED RELEASE BILAYERED OSMOTIC TABLET CARRYING SULFONYLUREA CLASS - ANTI DIABETIC AGENT & IMPERATIVE FACTORS IMPARTING SIGNIFICANT IMPACT ON DRUG RELASE
Journal Title: International Journal of Research in Pharmacy and Science - Year 2013, Vol 3, Issue 2
Abstract
Osmosis is an aristocratic biophenomenon, which is exploited for development of delivery systems with every desirable property of an ideal controlled drug delivery system. Osmotic system utilizes the principles of osmotic pressure for delivery of drug. Cellulose acetate NF (CA-398-10 NF) in a concentration of 8 % w/w for 10.0 mg tablet was optimized as coating polymer and Polyethylene Glycol 3350 NF in a concentration of 0.284%was optimized as pore former for Glipizide tablets. The manufacturing procedure was standardized and found to be reproducible. The values were found to be 7.28 and 72.65 (between T-1 & T-2), 2.37 and 85.69 (between T-1 & T-3) and 6.21 and 75.54 (between T-2 & T-3), respectively. One batch of three strengths were charged for stability studies at accelerated condition 40°C/75% RH, and at 25°C/60% RH in proposed pack i.e. HDPE Containers and 3 months stability data was found satisfactory. Thus the objectives envisaged in this study were arrived. Further studies are needed to investigate this formulation for its performance in vivo and its bioequivalence with the marketed product, Glucotrol XL. Extended release formulations of glipizide were developed based on push-pull osmotic technology.
Authors and Affiliations
Bhupatbhai Sharkheliya , Raju Sharma, Govind Rajawat S
Keywords
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