Formulation development and characterization of fast dissolving tablets of oxcarbazepine
Journal Title: Indian Journal of Pharmaceutical and Biological Research - Year 2015, Vol 3, Issue 1
Abstract
The objective of this study was formulation development and evaluation of Oxcarbazepine Fast Dissolving Tablets (FDTs) prepared by sublimation technique where different sublimating agents like camphor and menthol were used with L-HPC and crospovidone as a superdisintegrants. Oxcarbazepine is an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder. Each sublimating agent was used in concentration of 10-20 mg per tablet. Tablets were first prepared and then kept in hot air oven for sublimation. The prepared FDTs were evaluated for weight variation, thickness, drug content, friability, hardness, wetting time, water absorption ratio, in-vitro dispersion time, in-vitro disintegration time and in-vitro dissolution time. All formulations showed disintegration time ranging from 8 to 332sec. Optimized batch (SA6) was selected for the stability studies. The results of stability studies revealed that there was no remarkable difference in the tested parameters of promising formulation after storage for 3 months at 400c ± 20c 75% ± 5%RH and at room temperature 65% ± 5%RH as compared to initial results All the prepared formulae complied with Pharmacopoeia requirements of drug contents.
Authors and Affiliations
Krishnamurthy A. Kamalapurkar| D.S.T.S.Mandal’s College of Pharmacy, Shrikant Nagar, Vijapur road, JuleSolapur, Solapur, 413004, M.S. India, Mahesh P. Chitali| D.S.T.S.Mandal’s College of Pharmacy, Shrikant Nagar, Vijapur road, JuleSolapur, Solapur, 413004, M.S. India, Revansidh R. | D.S.T.S.Mandal’s College of Pharmacy, Shrikant Nagar, Vijapur road, JuleSolapur, Solapur, 413004, M.S. India, Pujari| D.S.T.S.Mandal’s College of Pharmacy, Shrikant Nagar, Vijapur road, JuleSolapur, Solapur, 413004, M.S. India
Keywords
Related Articles
- EP ID EP14726
- DOI -
- Views 342
- Downloads 13
Simultaneous Spectrophotometric Estimation of Telmisartan and Amlodipine Besylate in Tablet Dosage Form
A simple, accurate and reproducible spectrophotometric methods have been developed for the simultaneous estimation of Telmisartan (TEL) and Amlodipine Besylate (AML) in combined tablet dosage forms. The method involves...
A comparative study on different market samples and standard samples of Shalaparni through physicochemical methods and near infrared spectroscopy
Dashmoolais one of the most important groups explained in Mishrakagana. One of which, Shalaparni is a potent drug used single as well as in various formulations mentioned in classics. Adulteration in Dashmoolaplants is...
Antimicrobial activity of flavonoids from in vitro tissue culture and plant parts of two plant species of Western Rajasthan
Extract of flavonoids from plant parts and callus tissues of Glinus lotoides (molluginaceae) and Psoralea odorata (fabaceae) were screened against microbes’ viz., Bacillus cerus, Escherchia coli, Salmonella typhimuri...
Characterization of Bioactive compound isolated from Myrothecium spp. with UV, FTIR and HPLC Analysis
Development of new drugs, especially in area of infectious diseases, represents today one of the most important research. Fungal isolates are receiving increasing attention by natural product chemists due to their dive...
Aflatoxin Contamination in Agricultural Commodities
Aflatoxin is a naturally occurring Mycotoxin produced by Aspergillus flavus and Aspergillus parasiticus. Aspergillus flavus is common and widespread in nature and is most often found when certain grains are grown under...