Formulation development and evaluation of mefenamic acid microemulsion
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2015, Vol 3, Issue 4
Abstract
The present study was conducted to formulate Microemulsion of Mefenamic acid using Tween 80 as surfactant. Various formulations were prepared using pseudo ternary phase diagram and analysed. The thermodynamic stability and percent transmittance of formulations selected from the phase diagram was statistically significant. Therefore, microemulsion, a multipurpose technology, can be exploited in drug delivery for poorly soluble drugs. This technical note explains the basis for calculation and construction of pseudoternary phase diagrams and, most important, explains selection of the formulations from the phase diagrams to avoid metastable formulations having minimum surfactant concentration in the least possible time.
Authors and Affiliations
Vivek P. Chavda, Moinuddin M. Soniwala, Jayant R. Chavda
Keywords
Related Articles
- EP ID EP33327
- DOI -
- Views 263
- Downloads 0
Novel drug delivery of Minocycline aganist bacteria by using a polymer citric acid macro molecule
The main objective of the study is to synthesis 3rd generation of citric acid dendrimer and by attaching polyethylene glycol for reducing non specific systemic toxicity, increases the circulation time of the drug and s...
PHYTOCHEMICAL SREENING AND ANTIDIABETIC ANTIOXIDANT EFFECT OF ECBOLIUM LIGUSTRINUM FLOWERS EXTRACTS
The antidiabetic and antioxidant activity of Ecbolium ligustrinum (family:Acanthaceae) was investigated in alloxan induced diabetic albino rats. A comparison was made between both plant extracts and a known antidiabeti...
RP-HPLC method development and validation for simultaneous estimation of Lopinavir and Ritonavir in tablet dosage form
Simultaneous Estimation of Lopinavir and Ritonavir were carried out by RPHPLC using Acetate buffer (PH 6.5): Acetonitrile (55:45) and column Phenomenex Luna C-18 (250*4.6 mm, 5um) as a stationary phase and peak was obse...
Formulation and evaluation of losartan potassium ethosomal gel
Clinically liposomal systems were found to be effective, at forming drug reservoir in the upper layers of the skin for local skin therapy. Recently, it was found that Ethosomal carriers were phospholipid vesicular syst...
DRY EMULSION: A PROMISING DOSAGE FORM TO DELIVER LIPOPHILIC DRUG MOLECULES WITH IMPROVED STABILITY AND EFFECTIVENESS
Liquid emulsions have distinct advantages over the other oral dosage forms by improving the bio availability and by reducing the side effects, but the number of emulsion formulations currently in use are few compared w...