FORMULATION OF POLYMER-NANO COMPOSITE FILM FOR COATING GRASTRORETENTIVE TABLET OF DIPYRIDAMOL AS A MODEL
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 4
Abstract
Objective: The aim of this work was to formulate the polymer nano composite film to coat the gastroretentive tablet.Methods: The polymer nano composite film was formulated by varying the concentration of Eudragit® RS/RL 30D, PEG 6000 and with or without sodium bentonite. The polymer nano composite was then used to coat the gastroretentive dipyridamol tablet as a model.Results: The film containing Eudragit® RS/RL 30D at ratio 80:20 with 20 % PEG 6000 (w/w dry polymer) and 2% sodium bentonite (w/w dry clay) (formulation 16) was more elastic and strength. The diffusion test showed that the percentage of dipyridamole passed through the film of formulation 8 (without sodium bentonite) and 16 was superimposed during the 7 first hours and after 7 hours, they split in which the formulation 8 was higher than formulation 16. The floating lag time and capacity of the coated tablet with nano composite were 1’: 53†and more than 8 hours, respectively, while for tablet coated without nano composite were 0’: 09†and 7’: 08’: 27†respectively. The release showed that the gastroretentive dipyridamol tablet coated by polymer nano composite (formulation 16) released dipyridamol 43.59±3.59 and 89.69±4.92% at 4th and 8th hour respectively, while the tablet coated without nano composite (formulation 8) released 44.76±4. 74% and 95.76±1.35% respectively.Conclusions: The polymer nano composite film containing Eudragit® RS/RL 30D with the ratio of 80:20 and 20% PEG 6000 (w/w dry polymer) with the presence of 2% sodium bentonite generated tablet that floated for 8 hours and produced the release of the drug according to the requirement that has been set.Â
Authors and Affiliations
Saleh Wikarsa, Arevin Sandrasekeran, Diky Mudhakir
Keywords
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