FORMULATION, OPTIMIZATION AND IN-VITRO EVALUATION OF NIFEDIPINE SUSTAINED RELEASE TABLET
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 1
Abstract
The objective of the present study was to develop sustained release tablet of Nifedipine. The drug is a dihydropyridine derivative mainly indicated for the treatment of Hypertension. The drug belongs to the therapeutic classification as calcium channel blocker and antianginal. The tablets were prepared by wet granulation method.The granules were evaluated for angle of repose, bulk density, tapped density, compressibility index, and Hausner ratio. The tablets were subjected to thickness, hardness, friability, weight variations, and drug content by assay and in vitro dissolution studies. The granules showed satisfactory flow properties, compressibility index and drug content. All the tablet formulations showed acceptable pharmaceutical properties.The in-vitro drug release from Nifedipine sustained release tablet was carried out in 1.2 N HCl, and 6.8 pH phosphate buffer for 24hrs. The optimized formulation F3 showed the highest f2 (similarity factor) (f2 = 75.5) value. The drug release from the developed formulation was independent of agitational intensity. The release rate was influenced by medium, the amount of rate controlling polymer. The similarity factor, f2 was applied between the optimized formulation and the theoretical dissolution profile. The comparison of optimized formulation with marketed product gave a satisfactory release profile. The drug release data were plotted using various kinetic equations (Zero order, First order, Higuchi’s kinetics, Korsmeyer and Peppas kinetics and Hixson and Crowell kinetics) to evaluate the drug release mechanism and kinetics. The formulations were found to be stable for after 2 months of accelerated stability studies.
Authors and Affiliations
Pasupathi A, Palanisamy P, B Jaykar, R Margret Chandira, BSVenkateswarlu
Keywords
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