FORMULATION STUDIES ON CYCLODEXTRIN COMPLEXES OF MELOXICAM
Journal Title: International Journal of Pharmacy and Technology - Year 2010, Vol 2, Issue 1
Abstract
b-Cyclodextrin (b-CD) and HP-b-Cyclodextrin (HP-b-CD) inclusion complexes of meloxicam (M) exhibited higher dissolution rates and dissolution efficiency values than the corresponding uncomplexed drug. The feasibility of formulating the b-cyclodextrin and P-b-cyclodextrin complexes of meloxicam (1:3) into tablet dosage forms is evaluated. Solid inclusion complexes of meloxicam prepared by kneading method were formulated into tablets by wet granulation and direct compression methods. All the tablets formulated employing b-cyclodextrin and HP-b-cyclodextrin complexes of meloxicam gave rapid and higher dissolution rates of when compared to that of meloxicam plain tablets. All the prepared tablets fulfilled the official (I.P.) disintegration time specification of uncoated tablets. Overall, tablets prepared by direct compression method disintegrate rapidly when compared to those prepared by wet granulation method. Analysis of dissolution data as per zero-order and first – order kinetic models indicated that the dissolution of meloxicam from all the tablets followed first-order kinetics. In both direct compression and wet granulation methods, tablets formulated employing cyclodextrin complexes (MT2, MT3, MT5, MT6) gave higher rates of dissolution (K1) and dissolution efficiency (DE30) values when compared to the corresponding tablets formulated with meloxicam as such (MT1, MT4). Among all the meloxicam tablets formulated, formulation MT2, which is based on M- βCD (1:3) kneaded complex, gave highest dissolution. A 25.66 fold increase in the dissolution rate of meloxicam was observed with MT2 when compared to its plain tablets ( MT1).
Authors and Affiliations
Nagabhushanam M. V
Keywords
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