Frequency of Hepatitis Delta Virus in Hepatitis B Surfaceantigen-positive Patients
Journal Title: Viral Hepatitis Journal - Year 2019, Vol 25, Issue 1
Abstract
Objectives: The prevalence of hepatitis delta virus (HDV) worldwide shows geographical differences. Although there are several studies on anti-HDV seroprevalence rates in hepatitis B surface antigen (HBsAg)-positive patients in Turkey, studies on HDV-RNA prevalence in this patient population are limited. It was aimed to detect the frequency of anti-HDV antibodies and HDV-RNA in HBsAg-positive patients in this study. Materials and Methods: This retrospective study included 2089 HBsAg-positive patients in whom anti-HDV was analyzed between April 2015 and March 2017. Anti-HDV test was performed in serum samples obtained from HBsAg-positive patients by enzyme-linked immunosorbent assay. In anti-HDV-positive patients, HDV-RNA was analyzed in serum samples by real-time polymerase chain reaction. Results: The seroprevalence of anti-HDV was 4.1% (85/2089), while the rate of HDV-RNA positivity was 2.4% (51/2089). HDV-RNA was detected in 60% (51/85) of anti-HDV-positive patients. The frequency of anti-HDV and HDV-RNA was highest in the 50-59 age group. Conclusion: The frequency of HDV in this study was found to be consistent with regional data. HDV viremia was detected in only 60% (51/85) of the anti-HDV-positive patients. Since anti-HDV antibodies may remain after recovery, it is important to investigate HDV-RNA to determine the true prevalence of HDV.
Authors and Affiliations
Ayfer Yolcu, Nuran Karabulut, Sema Alaçam, Mustafa Önel, Melek Büyük, Mine Güllüoğlu, Ali Ağaçfidan
Keywords
Related Articles
- EP ID EP684564
- DOI 10.4274/vhd.galenos.2018-0018
- Views 149
- Downloads 0
Prevalence of Hepatitis B and C Infection in Patients with Rheumatoid Arthritis in Marrakesh
Objectives: Although there is no difference in frequency of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection in patients with rheumatoid arthritis (RA) in general population, multicenter studies are needed a...
Chronic Hepatitis C Prevalence and Physician Awareness in Southeastern Turkey
Objectives: This study aimed to investigate anti-hepatitis C Virus (HCV) positivity and physician-patient awareness in Southeastern Turkey. Materials and Methods: Age, gender and laboratory data of all patients aged 17...
http://viralhepatitisjournal.org/archives/archive-detail/article-preview/the-effect-of-switch-treatment-on-liver-fibrosis-a/40275
Objectives: To investigate the seroprevalence of hepatitis A virus (HAV) infection in children with chronic hepatitis B virus (HBV) infection and to immunize patients who did not have anti-HAV immunoglobulin (Ig) G level...
Occult Hepatitis B in Hemodialysis Patients
Objectives: We aimed to detect occult hepatitis B (OHB) in hemodialysis patients at a higher-risk for OHB. Materials and Methods: The study included 567 patients with chronic renal failure aged 18 years and older who un...
Molecular Characterization of Hepatitis B Virus Strains Isolated from Chronic Hepatitis B Patients in Southeastern Region of Turkey
Objectives: The aim of the present study was to assess the molecular aspects of HBV strains isolated from chronic hepatitis B (CHB) patients, in the Southeastern region of Turkey. Materials and Methods: The study involv...