Gamma-Aminobutyric Acid-Mediated Neurotransmission Inhibition in the Pontine Reticular Formation: A Potential Mechanism of Propofol Anesthesia

Journal Title: Science Insights - Year 2015, Vol 13, Issue 2

Abstract

Study for underlying anesthetic mechanisms is the key point of general anesthesia. Propofol is a representative of general anesthetics. Many general anesthetics are thought to produce a loss of wakefulness, in part, by enhancing Gamma-aminobutyric acid (GABA) neurotransmission. However, GABAergic neurotransmission in the pontine reticular formation promotes wakefulness. We hypothesized that propofol inhibited GABA current and promoted long-term potentiation (LTP) of pontine tissue,which might be the underlying mechanism of propofol anesthesia. In our pre-study investigation, propofol enhanced GABA current in the thalamic neuron and showed as a characteristic of burst discharge, but burst inhibition was observed in the pontine neuron. Hence, the hypothesis of the GABAergic neurotransmission inhibition in the pontine reticular formation might be the mechanistic base of propofol anesthesia, and given an experimental basis of the theory of central nervous inhibition in general anesthesia.

Authors and Affiliations

Fred Wang

Keywords

Related Articles

Practical Analysis of Mental Health Assistance in Elementary and Middle Schools under COVID-19 Pandemic: A Case Study of City A in Jiangsu, China

The COVID-19 outbreak has severely affected the mental health of elementary and middle school students in China, and has had a negative impact. How to help elementary and middle school students overcome the negative psyc...

Can We Put an End to Commercial Sex?

Sex workers contend that the emergence of the sex business may be traced back to the pursuit of commercial profits. Several economic issues, including economic inequality, according to sex workers, are at the basis of co...

Historical and Practical Perspective of the Unique Surface Electrical Properties of Cancer Cells

The fact that cancer cells have abnormal surface electrical charges has been discovered for more than half a century and yet it still has not been understood well despite of enormous efforts in cancerous research. Due to...

Accuracy of Palpation for Cricothyroidotomy

Cricothyroidotomy is a practical procedure that is critical for patients in the context of emergency. Accurately identify the cricothyroid membrane takes a crucial part in determining the success of cricothyroidotomy. Ho...

Duodenogastrojejunum Annular Internal Drainage for Superior Mesenteric Artery Syndrome: A Modified Staveley’s Surgery

INTRODUCTION: Superior mesenteric artery syndrome (SMAS) is caused by acute or chronic compression of the third part of the duodenum in the aortomesenteric angle. Staveley’s duodenojejunostomy (DJ) is an option when cons...

Download PDF file
  • EP ID EP689587
  • DOI 10.15354/si.15.hp008
  • Views 190
  • Downloads 0

How To Cite

Fred Wang (2015). Gamma-Aminobutyric Acid-Mediated Neurotransmission Inhibition in the Pontine Reticular Formation: A Potential Mechanism of Propofol Anesthesia. Science Insights, 13(2), -. https://europub.co.uk./articles/-A-689587