Genotoxic and Cytotoxic Effects of Cone Beam Computed Tomography on Exfoliated Buccal Epithelial Cells
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 3
Abstract
Cone beam Computed Tomography (CBCT) is a valuable diagnostic aid. It provides three dimensional detailed images of the region of interest with good quality. It allows volumetric analysis and it has short scan times. Ionizing radiation emitted from different radiographic procedures may induce DNA damage and genomic alteration. Genomic damages can be assessed and evaluated by numerous methods. The present study was accomplished to evaluate genotoxicity and cytotoxicity in exfoliated buccal mucosa cells of adults following CBCT exposure. Materials and Methods: 30 healthy male patients were recruited from outpatient’s clinic of Faculty of Dentistry Pharos University of age ranging from 27 to 43 years. All patients were submitted to CBCT. Exfoliated buccal cells were collected immediately before CBCT and after 10 days. The cytological smears were examined to detect micronuclei and other cytological alterations. Results: The mean frequencies of micronuclei and the other nuclear changes (pyknosis, condensed chromatin and karyorrhexis) showed a significant increase after CBCT exposure. Though, the increase in both parameters was not statistically significant in correlation with patients’ age. Conclusion: From the current study, the authors concluded that CBCT has inevitable health side effects. Hence, it must be used following the ALARA principle.
Authors and Affiliations
Soha Basha, Marwa Essawy
Keywords
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- EP ID EP369182
- DOI 10.9790/0853-1703056670.
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