Genotoxic Effect of Garlic Extract on Root Tips of Allium Cepa L
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 2
Abstract
The experiment was carried out to study the inhibition of the root growth and cytotoxic effects of garlic aqueous extract on onion bulbs (Allium cepa L.). The onion bulbs were treated with different concentrations of garlic aqueous extract (0, 5, 10, 15, 20 mg / l) for 72 hours in plastic laboratory tubes. The results indicated that the mitotic index and root growth rate of onion were considerably decreased in comparison to the control. We found that the cytotoxic effect of garlic extracts depends on the concentration and the exposure time. The EC50 value of garlic extract was 5 mg/l after 72 hours and the mitotic index value was (9%) at the same concentration (5 mg/l). The chromosomal aberrations were found to be increased as the concentration of the garlic extract increased when compared to control. The observed chromosomal abnormalities were chromosomal bridge, nuclear lesion, sticky chromosome and abnormal metaphase. We conclude that garlic extract have a genotoxic effect on the root tip cells of onion bulbs.
Authors and Affiliations
Essam A. A. Sadaqa1, Saeed S. Mohammed, Sameer H Qari2, Khaled S. Ali1
Keywords
Related Articles
- EP ID EP383491
- DOI 10.9790/3008-1102024144
- Views 91
- Downloads 0
Haemoproteus Columbae Infection and its Histopathological Effects on Pigeons in Qena Governorate, Egypt
Several health problems can affect pigeons but parasitic infections play a major role. The genus Haemoproteus includes a large number of intracellular protozoan parasites. A total of 103 pigeons were captured from differ...
The revisitation of an ancient recipe by the personal physician of Empress Maria Theresa of Austria for totally delousing garment and clothes both infested or destined to be infested
Clothes and garment delousing has been for centuries a very important trouble and manifold researches had attempted to loose the problem, employing heat or cold vapours of petroleum derivatives, or camphor or naphthalene...
Encephalitis: A Comparative Study in Pediatric and Adult Age Groups”
Encephalitis is a neurological disease cause by various agents, which may be viral, bacterial, amebic, parasitic, fungal etc. Again, Immune mediated cause may also be the factor. Our study tried to check the severity ris...
A Review on Hyphenated Separation Techniques Used in Pharmaceutical Analysis
Hyphenated techniques combine chromatographic and spectral methods to exploit the advantage of both. Chromatography produces pure or nearly pure fractions of chemical components in a mixture.The development of the pharma...
A “Rocambolesque” Strategy To Combat Definitively Lichen Simplex Chronicus In Black Skinned People.
Scope of our study is to treat Lichen simplex chronicus that is very evident in white people so that all Researchers of the Occidental World focus their attention to this concern, forgetting to observe that the same Lich...