HEPATOPROTECTIVE ACTIVITY OF CHENOPODIUM ALBUM LEAVES EXTRACT IN CCl4 INDUCED HEPATOTOXICITY IN RATS
Journal Title: Journal of Drug Delivery and Therapeutics - Year 2015, Vol 5, Issue 2
Abstract
Objective- Hepatoprotective activity of Chenopodium album leaves extract in CCl4 induced hepatotoxicity in rats. Method- The present study has been undertaken to evaluate hepatoprotective activity of Chenopodium album leaves extract in CCl4 induced hepatotoxicity in rats. The study was carried out by comparing SGOT, SGPT, Alkaline Phosphate, Direct Bilirubin, Total Bilirubin and Total proteins level in serum of different groups of rats. Histopathological study was also done on liver tissue of the all group of animals and compared with standard, positive control and negative control groups. Result- Rats treated with Chenopodium album leave extract caused a significant reduction in SGOT, SGPT, Alkaline phosphate, direct bilirubin, total bilirubin. Level of total proteins was found retrieving towards normalcy. Level of these enzymes was almost comparable to standard drug i.e. Silymarin. Hepatoprotective activity was confirmed by histopathological study of liver tissue of control and treated animals. Conclusion- From results it can be concluded that Chenopodium album possess hepatoprotective activity against CCl4Â induced liver toxicity in rats
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- EP ID EP487609
- DOI 10.22270/jddt.v5i2.1063
- Views 67
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