Hepatoprotective Effect of Glycyrrhiza Glabra in Carbon Tetrachloride-Induced Model of Acute Liver Injury
Journal Title: Journal of Physiology and Pharmacology Advances - Year 2012, Vol 2, Issue 7
Abstract
Acute liver injury is a serious state of extensive damage of liver tissue caused by various reasons. Certain medicinal plants had been used to cure some liver diseases. The present study was done to evaluate the hepatoprotective effect of aqueous extract of Glycyrrhiza glabra roots in rabbit models with acute liver injury induced by Carbon tetrachloride at a dose of 1.25 ml/kg as a mixture with olive oil. Aqueous extract of G. glabra was administered in a dose of 2gm/kg/day orally for 7 days. Its protective effect was assessed via liver function tests and histopathological liver sections. Significant reduction in the hepatic enzymes levels, serum bilirubin and improvement of serum protein was found in animals treated with the extract as well as restoration of hepatocellular architecture, absence of necrosis with mild degree of fatty infiltration. Our results demonstrate that the aqueous extract of G. glabra had a significant effect in amiolerating liver functions as well as restoring hepatic tissue in acute liver diseases when it was given in a single dose per day of 2gm/kg body weight. Therefore the aqueous extract of G. glabra roots can be used for prevention and treatment of liver disorders.
Authors and Affiliations
R. A. M. Al-Razzuqi , F. H. Al-Jawad , J. A. Al- Hussaini , A. A. Al-Jeboori
Keywords
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