Modulatory Activity of Aqueous Extract of Carica Papaya Seed on carbon Tetra-Chloride-Induced Hepatotoxicity in Wistar Rats
Journal Title: Journal of Physiology and Pharmacology Advances - Year 2012, Vol 2, Issue 5
Abstract
The effect of aqueous extract of ripe Carica papaya seed on liver function enzymes of CCl4 induced hepatotoxic liver was studied. Thirty (30) adult Wister rats were randomly divided into five (5)experimental groups. (n=6). Group A, were fed with rat chow and water ad labium and Groups B,C, D and E received 0.8mg/kg of CCl4 toxicant and Group C,D and E were treated with 100mg/kg, 200mg/kg and 300mg/kg of the extract respectively for 28 days. After an overnight fast, the rats were sacrificed and blood collected for assay of liver function enzyme levels. The results showed a statistically significant (p< 0.05) increase in the level of all liver function enzymes in the CCl4 only treated group (Group B) compared to the control and a dosedependent decrease in the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP)and bilirubin in extract treatment groups compared to group B. Therefore Carica papaya has a hepatoprotective effect and could be used as an adjunct in management of acute liver injury.
Authors and Affiliations
N. Eze Kingsley
Keywords
Related Articles
- EP ID EP156941
- DOI -
- Views 109
- Downloads 0
Massive Haemothorax and Tension Pneumothorax Due to Fractured Second Rib: Case Report
Massive haemothorax and tension pneumothorax due to injury of internal thoracic vein and second rib fracture after blunt trauma is very rare. Possible mechanisms of injury to the thoracic vein include fracture of an bony...
Clinical Effects of Probiotic Supplementation on Type-2 Diabetic Iraqi Patients Associated With Dyslipidemia
The consumption of probiotics is a new therapeutic strategy in preventing or delaying the onset of diabetes. Probiotics: are living, non-pathogenic micro-organisms (usually bacteria) which, when administered in sufficien...
Combined Antimicrobial Effect Against Some Isolated Bacteria from Chickens
This study evaluates the activity of amoxicillin in combination with flumequine against some resistant strains. A total of 100 samples were collected from clinical diseases chickens in farms located in Sharkia governorat...
Glucose Transporter 1 Gene Expression in Developmentally Regulated in Vitro derived Ovine Preimplantation Embryos
Precise control of gene expression during the preimplantation phase of development is important. The present study examined the expression pattern of GLUT 1 gene transcripts at various preimplantation developmental stage...
In Vitro Anthelmintic Effect of Aqueous and Ethanol Extract of Aristolochia Indica Against Haemonchus Contortus
Haemonchus contortus is the highly pathogenic nematode parasite of small ruminants causing haemorrhagic anemia, mortality and heavy loss in production. Development of resistance to the currently used anthelmintics has re...