High Sensitivity RT-qPCR Assay of Nonlabeled siRNA in Small Blood Volume for Pharmacokinetic Studies: Application to Survivin siRNA

Journal Title: The AAPS Journal - Year 2015, Vol 17, Issue 6

Abstract

The online version of this article (doi:10.1208/s12248-015-9812-y) contains supplementary material, which is available to authorized users.

Authors and Affiliations

Bertrand Z. Yeung, Ze Lu, Guillaume M. Wientjes, Jessie L. -S. Au

Keywords

Related Articles

Regioselective Glucuronidation of Andrographolide and Its Major Derivatives: Metabolite Identification, Isozyme Contribution, and Species Differences

The online version of this article (doi:10.1208/s12248-014-9658-8) contains supplementary material, which is available to authorized users.

Pancreatic Cancer: Pathobiology, Treatment Options, and Drug Delivery

Pancreatic cancer is the fourth leading cause of cancer-related deaths in the USA. The high mortality rate is partly due to lack of effective treatments. This review summarizes the pathobiology and current treatment opti...

Pharmacodynamics of Telomerase Inhibition and Telomere Shortening by Noncytotoxic Suramin

We reported that suramin is an effective chemosensitizer at noncytotoxic concentrations (<50 μM); this effect was observed in multiple types of human xenograft tumors in vitro and in vivo. Clinical evalua...

Toward Global Standards for Comparator Pharmaceutical Products: Case Studies of Amoxicillin, Metronidazole, and Zidovudine in the Americas

The online version of this article (doi:10.1208/s12248-012-9350-9) contains supplementary material, which is available to authorized users.

Addressing the Challenges of Low Clearance in Drug Research

As a result of high-throughput ADME screening, early metabolite identification, and exploration of novel chemical entities, low-intrinsic-clearance compounds continue to increase in drug discovery portfolios. Currently a...

Download PDF file
  • EP ID EP681027
  • DOI  10.1208/s12248-015-9812-y
  • Views 50
  • Downloads 0

How To Cite

Bertrand Z. Yeung, Ze Lu, Guillaume M. Wientjes, Jessie L. -S. Au (2015). High Sensitivity RT-qPCR Assay of Nonlabeled siRNA in Small Blood Volume for Pharmacokinetic Studies: Application to Survivin siRNA. The AAPS Journal, 17(6), -. https://europub.co.uk./articles/-A-681027