High Sensitivity RT-qPCR Assay of Nonlabeled siRNA in Small Blood Volume for Pharmacokinetic Studies: Application to Survivin siRNA
Journal Title: The AAPS Journal - Year 2015, Vol 17, Issue 6
Abstract
The online version of this article (doi:10.1208/s12248-015-9812-y) contains supplementary material, which is available to authorized users.
Authors and Affiliations
Bertrand Z. Yeung, Ze Lu, Guillaume M. Wientjes, Jessie L. -S. Au
Regioselective Glucuronidation of Andrographolide and Its Major Derivatives: Metabolite Identification, Isozyme Contribution, and Species Differences
The online version of this article (doi:10.1208/s12248-014-9658-8) contains supplementary material, which is available to authorized users.
Pancreatic Cancer: Pathobiology, Treatment Options, and Drug Delivery
Pancreatic cancer is the fourth leading cause of cancer-related deaths in the USA. The high mortality rate is partly due to lack of effective treatments. This review summarizes the pathobiology and current treatment opti...
Pharmacodynamics of Telomerase Inhibition and Telomere Shortening by Noncytotoxic Suramin
We reported that suramin is an effective chemosensitizer at noncytotoxic concentrations (<50 μM); this effect was observed in multiple types of human xenograft tumors in vitro and in vivo. Clinical evalua...
Toward Global Standards for Comparator Pharmaceutical Products: Case Studies of Amoxicillin, Metronidazole, and Zidovudine in the Americas
The online version of this article (doi:10.1208/s12248-012-9350-9) contains supplementary material, which is available to authorized users.
Addressing the Challenges of Low Clearance in Drug Research
As a result of high-throughput ADME screening, early metabolite identification, and exploration of novel chemical entities, low-intrinsic-clearance compounds continue to increase in drug discovery portfolios. Currently a...