Histologic Effect of Garlic Extract on the Spleen of Adult Wistar Rat
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 17, Issue 2
Abstract
One of the plant commonly consumed in Nigeria for dietary and therapeutic purpose is Garlic (Allium sativum). Often time, the effect of the plant on the spleen is not considered by users. This present study is to investigate the histologic effect of garlic extract on the spleen of adult Wistar rats. This was a descriptive experimental study involving twenty-four (24) adult wistar rats as experimental animals. Twenty-four (24) adult Wistarrats weighing between 150-250 g were used for this research. The experimental animals were obtained from the Animal House of the faculty of Basic Medical Sciences, Delta State University, Abraka. The animals were randomly assigned into four (4) groups. The control group were given distilled water and rat chow. The treatment group (Group 2, 3, 4) received100mg/kg, 200mg/kg and 300mg/kg respectively of body weight of aqueous garlic extract, rat chow and water. Histological results from this study indicate that higher doses of garlic extract has effect on the cells of the spleen (white pulp, red pulp, lymphoid tissue, trabeculae) and even the outer capsule of the wistar rats.
Authors and Affiliations
Udi Onoriode Andrew, Lilian Ebele Chris Ozoko, Iteire Afoke Kingsley3 ,, Enaohwo T. Mamerhi2 ,, Ewere Beauty
Keywords
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- EP ID EP390110
- DOI 10.9790/3008-1204050104
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