Histomorphological study of corneal dystrophies
Journal Title: Indian Journal of Pathology and Oncology - Year 2018, Vol 5, Issue 1
Abstract
Introduction The term Corneal Dystrophy refers to a rare heterogeneous group of genetically determined bilateral symmetric primary diseases restricted to cornea and not associated with previous ocular inflammation The dystrophies are classified based on the layer of cornea involved into superficial stromal and posterior dystrophies each of which is genetically determined Though the clinical features are often characteristic definitive diagnosis is possible only after histological examination The management protocols and visual prognosis vary with the underlying conditions The incidence of the subtypes varies with the geographic locationsObjective To study the prevalence of various subtypes of Corneal Dystrophies in corneal button specimens obtained after penetrating keratoplasty in a referral ophthalmic institute and to correlate with the patients age and sexMaterials and Methods Corneal button specimens received in the ocular pathology laboratory over a period of five years were reviewed Histopathological features of Corneal Dystrophies were studied and subcategorised Cliniopathological analysis was madeResults Out of 660 corneal biopsies reviewed 42 cases were of corneal dystrophy The patients were between 2 and 71 years of age with 14 males and 28 females Macular dystrophy was the most common with 20 cases followed by Congenital Hereditary Endothelial Dystrophy CHED and Fuchs endothelial dystrophy FECD with 7 cases each Epithelial basement membrane dystrophy Reis Buckler Dystrophy RBCD Granular dystrophy were the other typesConclusion Histopathological sub categorisation of various types of Corneal Dystrophies not only helps in understanding the prevalence but also in predicting the genetic link and prognosis of the disease categoryKeywords Cornea CHED Dystrophy Fuch Macular
Authors and Affiliations
Thejaswini MU, Geethamani V, Sushma TA, Suguna BV, Bhargavi Mohan
Keywords
Related Articles
- EP ID EP473201
- DOI 10.18231/2394-6792.2018.0026
- Views 58
- Downloads 0
Histopathological spectrum of cholecystectomy specimens in a tertiary care hospital in Bangalore
Introduction Gallstone disease is a major health problem and puts notable burden on individuals and health care system worldwide This research was carried out to study the varied histopathological changes in the gallblad...
Spectrum of lesion on testicular FNAC excluding infertility cases: A retrospective analysis of cases
Introduction The incidence of testicular lumps has continuously increased in recent decades FNAC serves as an important tool to diagnose and provide sufficient information for the initiation of treatment without need for...
Histopathologic correlates of clinically verrucous lesions
Introduction Verrucous lesions present as cauliflower like slowly growing masses which may be single multiple or diffuse involving the broad areas of skin or mucosal surfaces Clinically these lesions are diagnostic chall...
Histomorphological spectrum of colonic biopsies: A two year study
Introduction Colonoscopy and accompanying mucosal biopsy is the diagnostic tool of choice in the evaluation of patients with colo rectal pathologies The objectives of this study were to study the histo morphological spec...
Histopathological study of ovarian tumours
Ovarian tumours are common neoplasms in females and have diverse histopathological entities as they are derived from different cells of origin Histopathological patterns and incidence of 121 ovarian tumours were studied...