Homocysteine and Atherogenic lipid profile as Markers of Atherotherombatic Disease among Sudanese Patients with Diabetes Mellitus
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2017, Vol 5, Issue 9
Abstract
Abstract:Atherosclerosis is associated with increased inflammatory activity and risk of vascular disease.However, the factors that promote inflammation are not apparently clear. The aim of the present study was to detect homocysteine (Hcy) in urine as a marker for a therothombatic disease among Sudanese patients with Type2 diabetes mellitus with other markers as predictors of cardiovascular disease. A case control study , was conducted included a total of 100 individuals (60 patients and 40 apparently healthy) age was matched in both groups (ranged from 35 to 75 years) 65% male and 35% female, atherogenic lipid profile and HbA1c were measured by Biosystem 350 and Hcy was detected qualitativly by using Spaeth and Barber Modification method Silver – Nitroprusside test. Data analysis was done by using SPSS version 21 and the results revealed that 25 % of the patients had Hcy positive (+ve) while 35 % had Hcy negative (-ve). There was a significant increase of level of total cholesterol, LDLc, HbA1c and significant decreased level of HDLc between study groups. No statistical deffirance was found in levels across gender of patients. The results showed a positive correlation between total cholesterol, LDLc, HDLc and duration while a negative correlation was found with duration and HDLc. Positive correlation was found between BMI and HbA1c, total cholesterol, LDLc, HDLc. In conclusion, Homocysteine is related to CVD risk mildly elevated of homocysteine being an independent risk factor for atherothrombatic disease among Type2 Diabetes Mellitus. Keywords:Homocystine, Cardiovascular disease, Atherogenic lipid, HbA1c, BMI
Authors and Affiliations
AbdelA zizHamza, Mariam Abbas Ibrahim
Keywords
Related Articles
- EP ID EP371393
- DOI -
- Views 63
- Downloads 0
An Overview of Current Treatments of Migraine
Abstract: The name ‘migraine’ has its origin from the Greek word hemicrania, which means ‘half of the head’, indicating the main feature of migraine i.e it affects only half portion of the head. It is the most widespread...
Judges’ Opinion on Doctors’ Legal Responsibility in the District of Bamako
Doctors’ legal responsibility is a challenging issue in medical practice. Lawsuit against Doctors is growing worldwide. In some countries, there is mistrust and disagreement between Judges and Doctors.The purpose of our...
Study of Clinico-Radiological Risk Factors and Laboratory Parameters in Association with Post Stroke Vascular Cognitive Impairment
Abstract: Cognitive impairment due to cerebrovascular disease is termed.” vascular cognitive Impairment “(vici,) and forms a spectrum that includes vascular dementia and milder forms of cognitive impairment referred to a...
Isolation, Identification and Antimicrobial Susceptibility Pattern of Escherichia Coli Isolated From Urine Samples at Tertiary Care Hospital
Urinary tract infection (UTI) is the most common bacterial infection caused by both gram negative bacilli and gram positive cocci among which E. coli remains the leading uropathogens involving both men and women of all a...
Pulmonary Function Test in Stone Crusher Plant Workers
Stone crushing in India is a small scale industry where a large number of laborers work. Workers at stone crushing site are exposed to silica dust which leads to pulmonary function deterioration. The objective of this st...