Identification and component analysis of triterpenoids in Monarda fistulosa L. and Ocimum americanum L. (Lamiaceae) aerial parts
Journal Title: ScienceRise: Pharmaceutical Science - Year 2018, Vol 0, Issue 3
Abstract
<p class="xfmc1">Despite the progress in the creation of synthetic drugs, herbal medicines do not lose their relevance nowadays. Triterpenoids are quite common in the plant world and exhibit a wide range of biological activity. Medicinal plants of the Lamiaceae family can accumulate mainly pentacyclic triterpenoids which demonstrate the anti-inflammatory, antioxidant, hepatoprotective, anticancer and antimicrobial properties. Nowadays a number of new, poorly-studied species of the family have been introduced in Ukraine, including Monarda fistulosa L. and Ocimum americanum L.</p><p class="xfmc1">The <strong>aim</strong> of this study was to identify the triterpenoids and to analyze the contents of their components in ethanolic extracts of M. fistulosa and O. americanum (Lamiaceae) aerial parts under the condition of their farming in West Podillya (Ukraine).</p><p><strong>Methods: </strong>foam test, sedimentation and color reaction were used to determine the presence of triterpenoids in plant material; high-performance liquid chromatography (HPLC) method was used to determine their components' content; determination was carried out on a liquid chromatograph Shimadzu LC 20 Prominence.</p><p><strong>Results</strong>. The presence of triterpenoids in M. fistulosa and O. americanum ethanolic extracts was proved by the reactions of identification and HPLC. Effective extraction of triterpene compounds from the investigated plants was achieved using 96 % and 70 % ethanol. The comparative HPLC-analysis showed significant differences in content of ursolic, euscaphic, tormentic and oleanolic acids, betulin and lupeol in the aerial parts of investigated species. The most abundant components of M. fistulosa and O. americanum herbs were the ursolic and euscaphic acids.</p><strong>Conclusions</strong>: It was identified the presence and evaluated the contents of 6 triterpenoids in M. fistulosa and O. americanum aerial parts. The obtained data can be used in the planning of pharmacological studies and in the chemotaxonomy of Lamiaceae family
Authors and Affiliations
Mariia Shanaida, Olena Golembiovska
Keywords
Related Articles
- EP ID EP526836
- DOI 10.15587/2519-4852.2018.135767
- Views 148
- Downloads 0
Prediction of the competitiveness dynamics of pharmacy chains
<p>In market economy, one of the main tasks of any enterprise (organization) is to defeat rival competitors. It should not be single or random victory, but it should be natural result of effective management of this proc...
Порівняльний аналіз асортименту лікарських засобів для фармакотерапії дитячого церебрального паралічу в Україні та за Британським Національним Формуляром
<p><strong>Мета. </strong>Вдосконалення асортименту лікарських засобів для лікування дитячого церебрального паралічу в Україні.<strong></strong></p><p><strong>Методи.</strong> Системний аналіз; маркетингові дослідження;...
Synthesis of potential antiexudative preparations for 2-((4-amino-5-(furan-2-il)-1,2,4-triazole-(4H)-3-yl)-sulfanyl)-N-acetamide series
<p><strong>Aim.</strong> Conduct the purposeful synthesis of new potential biologically active substances of derivatives of 2 - ((4-amino-5- (furan-2-yl) -1,2,4-triazol (4H) -3-yl) -sulfanyl) -N-acetamides and evaluate t...
Current state assessment of pharmaceutical care implementation in Ukraine
<p>At the modern stage of the pharmacy development, there were significant changes in the positioning of the pharmacist’s role in the health care system. It has contributed to the development of pharmaceutical care (PC)...
Products of interaction of substituted 5-aminopyrazoles with α -haloketones as potential pharmaceutical agents
<p><strong>Aim. </strong>Optimization of reaction of substituted 5-aminopyrazoles with a-haloketones to form annealed 2,6,7-trisubstituted 1H-imidazo[1,2-b]pyrazoles.</p><p><strong>Materials and methods of research. </st...