Immunohistochemical Markers In Salivary Gland Tumors.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 9
Abstract
Tumors of salivary gland have diverse histological forms and unpredictable clinical behavior. The diverse site of origin and complexity of classification further compound the difficulties in diagnosis. The main application of immunochemistry in salivary gland tumors is to demonstrate the existence of myoepithelial /basal cells or luminal cells. Objectives: 1. To evaluate the myoepithelial marker p63 in various salivary gland tumors. 2.To study the expression of various IHC markers- CK,CD 117,Her2/neu , Ki67 in salivary gland tumors. Methods: Surgically resected specimens received at department of pathology, Thanjavur medical college were subjected to histopathological examination. Specimens were fixed in 10% formalin,processed and embedded in paraffin blocks, serially cut to get sections of 3-5microns thickness, stained with Hemotoxylin & Eosin and immunohistochemistry wherever necessary. Results: The total number of specimens were 92, of which 41were neoplastic (benign44.56% and malignant 25% ) 28 were nonneoplastic. Pleomorphic adenoma was the commonest benign tumor accounting for 73.17% of benign tumors. Mucoepidermoid carcinoma was the most common malignant tumor accounting for 52.18% of malignant tumors. Parotid was the common salivary gland involved followed by minor salivary and submandibular gland. Salivary gland tumors show slight female preponderance with male female ratio of 1:1.7. Expression of P63 in pleomorphic adenoma have confirmed the role of myoepithelial cells in the histiogenesis of this tumor and lack or minimal expression of P63 in mucoepidermoid indicates minimal myoepithelial cell differentiation in these tumors. Conclusions: Pleomorphic adenoma is the most common benign tumor ,common site being parotid. Basal cell adenoma is the second most common benign tumor. Mucoepidermoid is the most common malignant salivary and the most common site is parotid. Adenoid cystic carcinoma is the second most common malignant tumor. Histopathology is still the gold standard for diagnosis of salivary gland tumors. IHC do not di rect ly indicate a def ini te diagnosi s. It can enhance the accuracy and be a helpful tool when the diagnosis cannot be assessed by histological examination such as cell of origin, cell proliferation and tumor protein expression.
Authors and Affiliations
Dr. C. Mythily MD, Dr. B. Saranya MD
Keywords
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- EP ID EP256026
- DOI 10.9790/0853-1609045561
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