Impact of Osmotically Active Excipients on Bioavailability and Bioequivalence of BCS Class III Drugs
Journal Title: The AAPS Journal - Year 2013, Vol 15, Issue 4
Abstract
SAPP is commonly used as a food additive and mostly found in bakery products (40). SAPP can also be employed as an excipient for effervescent formulations to provide rapid disintegration of pharmaceutical products. In a relative bioavailability study on ranitidine, it was found that co-administration of 1,132 mg (5.1 mmol) SAPP significantly reduced ranitidine absorption (54% based on AUC), which was further shown to be in parallel to a 56% decrease in small intestine transit time using scintigraphic imaging (41).
Authors and Affiliations
Mei-Ling Chen, Nakissa Sadrieh, Lawrence Yu
Keywords
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- DOI 10.1208/s12248-013-9509-z
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