IN SILICO ADME AND TOXICITY STUDY OF SOME SELECTED ANTINEOPLASTIC DRUGS
Journal Title: International Journal of Pharmaceutical Sciences and Drug Research - Year 2016, Vol 8, Issue 1
Abstract
Cancer is a serious health problem that recognized as a group of diseases involving uncontrolled cell growth. Majority of cancer chemotherapeutic agents have serious toxicity profile. Due to this use of these agents are limited. Therefore, it is essential requirement for developing new chemotherapeutic agents to devoid toxicity. In this research work, we study the pharmacokinetic, toxicity and bioactivity profile of few selected chemotherapeutic agents by In silico method. These research investigations provide the lead for the development of new cancer chemotherapeutic agents with lesser toxicity and more effectiveness.
Authors and Affiliations
Chandra Shekhar Sharma, Shashank Shekher Mishra, Hamendra Pratap Singh, Neeraj Kumar
AMELIORATIVE EFFECT OF EUGENOL AND ANETHOLE ON ARSENIC INDUCED OXIDATIVE DNA DAMAGE IN CULTURED HUMAN PERIPHERAL BLOOD LYMPHOCYTES
Arsenic contamination is one of the major health concerns all over the world and associated with various types of cancer and pathological effects. The production of reactive oxygen species (ROS) plays a crucial role in a...
ANALGESIC AND ANTI-INFLAMMATORY EVALUATION OF ETHANOLIC EXTRACT OF SEENTHIL CHURANAM
The polyherbal formulation of Seenthil churanam is composition of whole plant extracts of Eclipta prostata, Tinospora cordifolia and the dried powder form of Earthworm used in folk medicine. The study was conducted to ev...
PROTECTIVE PROPERTIES OF FLAVONOID EXTRACT OF COAGULATED TOFU (CURDLED SOY MILK) AGAINST ACETAMINOPHEN-INDUCED LIVER INJURY IN RATS
The total flavonoid contents of the various coagulated tofu and the hepatoprotective potential of all tofu flavonoid extracts were investigated. Tofu was prepared from locally sourced coagulants (steep water, alum, lemon...
BIOACTIVITY AND DEREPLICATION OF PHENOLIC COMPOUNDS IN MEDICINAL PLANTS
Three medicinal plants with recognized anti-inflammatory potential, identified as “erva de São João“ (Ageratum conyzoides), “Tanchagem“ (Plantago major) and “ Bardana“ (Arctium lappa L.) were obtained from a medicinal he...
EVALUATION OF TRACK ETCH MEMBRANE AS A SURROGATE FOR EX-VIVO DRUG PERMEATION STUDIES
The track etch membranes has attracted the attention of researchers, as a kind of novel material, for their various applications such as precise separation of biological cells, detection of biomolecules and controlled dr...