IN VITRO AND IN SILICO APPROACH TO EVALUATE THE ANTI-DERMATOPHYTIC ACTIVITY OF ENICOSTEMMA LITTORALE BLUME
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 10
Abstract
Dermatophytes are the causative agents of superficial skin infections, dermatophytoses, which are capable of invading and digesting keratin. The current usage of synthetic drugs leads to either side effects in human or resistant fungal varieties due to prolonged use. Hence the present study aims at finding leads from phytocompounds to target the enzymes involved in maintaining fungal cell wall integrity, namely, 1, 3 β-D glucan synthase and chitinase, important enzyme having a role in morphogenesis. Docking analysis was carried out for the above targets with already reported phytocompounds of Enicostemma axillare (syn. littorale) Blume and compared with the specific synthetic drugs to evaluate their efficacy as fungal inhibitors using Glide software. The in vitro study was carried out for E. littorale extract against Microsporum gypseum. The significant results were observed with the petroleum ether extract of the aerial parts of E. littorale at a concentration of 3000 µg/ml.
Authors and Affiliations
Jeyam Muthusami , Muthuselvi Muthusamy , Manoharan Sharanya, Ramalakshmi Iyappan
Keywords
Related Articles
- EP ID EP115388
- DOI 10.7897/2230-8407.041018
- Views 105
- Downloads 0
CYCLODEXTRINS: AN EXCIPIENT TOOL IN DRUG DELIVERY
Cyclodextrins (CDs) are a family of compounds consist of glucose monomers arranged in a donut shape ring. They are non-reducing, crystalline cyclic oligosaccharides which proximate a truncated core generating a hydrophil...
ANTINOCICEPTIVE ACTIVITY OF COLD WATER EXTRACT OF DESMODIUM TRIFLORUM IN RATS
The aim of this study was to examine antinociceptive potential of cold water extract (CWE) of Desmodium triflorum (Family: Fabaceae / Leguminosae) plant. One of four doses of CWE (dose 4000 mg/ml, 2000 mg/ml and 1000 mg...
IN VITRO ANTIRHEUMATOID ARTHRITIC ACTIVITY OF AQUEOUS ROOT EXTRACT OF CLITORIA TERNATEA
In ethano medicine, roots of Clitoria ternatea (Family: Fabaceae) is claimed to possess antirheumatoid arthritic activity. However, this claim has not been scientifically tested and validated yet. This study assessed the...
DIFFERENCE SPECTROPHOTOMETRIC ESTIMATION OF PRASUGREL HYDROCHLORIDE IN BULK AND TABLET DOSAGE FORM
A simple, precise and accurate difference spectroscopic method has been developed for the estimation of prasugrel hydrochloride in bulk and in pharmaceutical dosage form. The proposed method is based...
DRY GRANULATION TECHNIQUE FOR CONVERTING TRIPHALA CHURNA AS GRANULES, TABLETS AND ORGANOLEPTIC EVALUATION
The objective of this research work was the conversion of Triphala churna into stable, palatable and patient acceptable granules to swallow conveniently by dry granulation methods, using suitable binding agents. The chur...