IN VITRO ANTHELMINTIC EFFECTS OF SENNA OCCIDENTALIS (L.) LINK (LEGUMINOSAE) ON RAT TAPEWORM HYMENOLEPIS DIMINUTA
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 6
Abstract
Objective: This study was conducted to evaluate the anthelmintic activity of ethanolic leaf extract of Senna occidentalis on rat tapeworm Hymenolepis diminuta.Methods: Adult H. diminuta worms were obtained from laboratory maintained infection in rats. Different concentrations of crude ethanolic leaf extracts of S. occidentalis were tested in vitro on H. diminuta and praziquantel (PZQ) was used as reference drug. The efficacy of plant was assessed on the basis of motility of the worms. The anthelmintic effects were also evaluated using scanning and transmission electron microscopy.Results: A dose dependent efficacy was observed in all the experiments. At the highest concentration (80 mg/ml), the mortality of worms was recorded in 12.82±0.24 hrs. The scanning electron microscope observations of extract treated worms showed irrevocable destruction all over the body tegument,which was accompanied with sloughing of microthriches and shrinkage of scolex. Whereas, the transmission electron micrography of treated worms revealed destruction of the syncytial layer along with sparse cytoplasmic cytons and depletion of parenchymatous layer. Exposure of basal lamina, decrease in an electron lucency in the nucleus and intense vacuolization was also observed in our study.Conclusion: In view of these observations, S. occidentalis may be regarded as potential anthelmintic plant and it could be exploited further for the development of a novel anthelmintic.Â
Authors and Affiliations
Suman Kundu, Saptarshi Roy, Suranjana Nandi, Bidisha Ukil, Larisha M. Lyndem
Keywords
Related Articles
- EP ID EP578700
- DOI -
- Views 75
- Downloads 0
ENHANCED APOPTOSIS IN MCF-7 HUMAN BREAST CANCER CELLS BY BIOGENIC GOLD NANOPARTICLES SYNTHESIZED FROM ARGEMONE MEXICANA LEAF EXTRACT
Objective: To assess the in vitro anticancer activity of A. mexicana mediated gold nanoparticles on MCF-7 breast cancer cells.Methods: The present study reveals the synthesis and characterization of gold nanoparticles fr...
ISOLATION, SCREENING, AND CHARACTERIZATION OF CHITINASE PRODUCING BACTERIA FROM MARINE WASTES
Objective: Aim of this study deals with screening and characterization of chitinase-producing bacteria from marine waste and its deposited soil along the coastal regions in Chennai.Methods: The soil samples were collecte...
EVALUATION OF TERATOGENICITY EFFECTS OF ETHANOLIC EXTRACTS OF BINAHONG LEAVES (ANREDERA CORDIFOLIA (TEN) STEENIS) IN WISTAR RAT
Objective: The aim of this study was to evaluate teratogenicity effect of ethanolic extract of binahong (Anredera cordifolia (Ten.) Steenis) leaves in Wistar rats.Methods: The teratogenicity test were done in 5 groups of...
DEVELOPMENT OF COSMOCEUTICAL PRODUCTS FROM NANO-SIZED ACTIVE COLOUR CONSTITUENTS OF RATANJOT, SEABUCKTHORN AND ANNATTO
Objective: The objective of this research was to develop the nano-particles of natural colours from Ratanjot root, Seabuckthorn pulp, and Annatto seeds and use them in cosmetic products. Multiple herbs were used to have...
FORMULATION AND EVALUATION OF MATRIX TABLET OF VENLAFAXINE HCL BY USING DIRECTLY COMPRESSIBLE CO-PROCESSED EXCIPIENT
Objective: The sustained release of drug from the dosage form is useful especially for achieving controlled plasma level of the drug as well as improving bioavailability. The objective of the present work was to release...