In Vitro Evaluation of Antiulcer Activity of A Polyherbal Mixture
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2018, Vol 8, Issue 12
Abstract
The present study was performed to assess the in vitro acid neutralizing capacity and H+ /K+ - ATPase inhibition activity of a chloroform extract of polyherbal mixture. In acid neutralizing capacity (ANC), the extract significantly reduced ANC to 7.3 at concentration of 1500mg as compared to 13.7 with standard Aluminium hydroxide+Magnesium hydroxide (500mg). While in H + /K+ - ATPase inhibition activity, the extract showed maximum percentage inhibition of 63.78% at the concentration 100µg as compared to 69.76% with standard Omeprazole. The IC 50 value of chloroform extract of polyherbal mixture is 53.43 µg in comparison with standard Omeprazole 56.45 µg. The study reveals that the chloroform extract of polyherbal mixture may contain compounds possessing antacid and enzyme inhibition activity and thus can be used as an alternative medicine for gastrointestinal diseases.
Authors and Affiliations
Sumia Fatima, Dr. C Ramesh, A Saheel Qureshi
Keywords
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