In Vitro Neuro-Protective Studies of Phyto-Compounds from Azadirachta indica, Centella asiatica and Gloriosa superba
Journal Title: UNKNOWN - Year 2018, Vol 8, Issue 8
Abstract
The test substances quercitin dehydrate, asiatic acid and colchicine were evaluated for its in vitro neuro-protective activity against Hydrogen peroxide induced toxicity in HEK-293-(Human embryonic kidney cell line). Firstly Test Substances were estimated for cytotoxicity with different concentrations ranging from 100 μg/ml to 1.56 μg/ml, which resulted high toxicity in HEK-293-(Human embryonic kidney) cell line, and hence the nontoxic concentrations were taken for further studies. In Cytoprotective studies Test Substances were showing significant activity in human embryonic kidney cells against hydrogen peroxide toxicant. These compounds are seen to express their activity in AMPA and SNCA expressed cells in HEK-293 cell line.
Authors and Affiliations
Preenon Bagchi, Ajit Kar, Anuradha M
Keywords
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