In vivo Antimalarial Activity of Areal Part Extracts of Gardenia lutea and Sida rhombifolia
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2013, Vol 2, Issue 1
Abstract
Malaria is an endemic disease which affects 40% of world’s population and it is distributed widely, mainly due to the multi-drug resistance developed by Plasmodium falciparum. It remains the leading cause of death among parasitic diseases. Resistance to all known antimalarial drugs, except for the artemisinin derivatives, has developed to various degrees in several countries. Hence, there is a huge demand to develop antimalarial drug. In line with this notion, the hydroalcoholic leaves extracts of Gardenia lutea and Sida rhombifolia were tested for their in vivo activity against Plasmodium berghei. The extracts showed significant antimalarial activity at doses of 200, 400 and 600mg/Kg. The plant extracts also exhibited safety profile at tested doses of 500, 1000 and 2000mg/Kg. To conclude, 80% methanol extracts of Gardenia lutea and Sida rhombifolia exhibits significant antimalarial activity with acceptable margin of safety.
Authors and Affiliations
Baye Akele
Keywords
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