In Vivo Antioxidant Activity of Bougainvillea Glabra
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2018, Vol 8, Issue 6
Abstract
The present study was aimed at investigating the in-vivo antioxidant activity of the methanol extract of Bougainvillea glabra. Methanol extract of Bougainvillea glabra was administered to rats at two different doses of 250 and 500 mg/kg for 21 days and to evaluate oxidative stress parameters such as ferric reducing ability of plasma (FRAP), thiobarbituric acid reactive substance (TBARS), reduced glutathione (GSH) and antioxidant enzyme levels [catalase (CAT) & superoxide dismutase (SOD)]. The methanol extracts of Bougainvillea glabra significantly (p < 0.05) elevated the ferric FRAP on 7, 14 and 21 days of treatment. Significant (p<0.05) decrease of TBARS level along with an increase in the SOD & CAT enzymes level in the liver and kidneys at two different doses of the plant was observed. However, there was no major effect of TBARS, SOD, CAT and GSH levels in heart at two different doses of Bougainvillea glabra. The above results recommend that Bougainvillea glabra have potent antioxidant activity, which were responsible for its reported pharmacological activity.
Authors and Affiliations
P. M Herath,, P. Vijitha, R. Piratheepkumar
Keywords
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