A Study of Variations in Serum Cortisol and Urinary Spot Creatinine Levels in Traumatic Brain Injury Patients
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2013, Vol 3, Issue 8
Abstract
Traumatic Brain Injury (TBI) due to road traffic accidents is one the leading cause of death in India. Though several radiological diagnostic modalities are available to visualize the extent of injury, no perfect biomarkers are available to access the clinical condition of the patients. Since serum cortisol and urinary creatinine excretion are associated with the patho-physiology of TBI, we aimed to find the association between their levels and the clinical condition of the patients. Totally 54 TBI patients categorized as mild (n=23), moderate (n=15) and severe (n=16) based on their admission day GCS scores were analyzed for serum cortisol and urinary creatinine at the day of admission and discharge. Both serum cortisol (<0.0001), and urinary spot creatinine (<0.0001) showed a significant difference in their levels between the admission and discharge day. Serum cortisol levels showed a significant correlation among mild and moderate categories. Urinary spot creatinine levels correlated significantly among mild and severe categories. Serum cortisol and urinary spot creatinine are found to be important biomarkers of neurotrauma.
Authors and Affiliations
Sivaa R, , Thiagarajan G
Keywords
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