INCIDENCE OF IMPAIRED GLUCOSE METABOLISM IN PATIENTS STARTED ON TREATMENT FOR HIV AND PTB CO-INFECTION
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 92
Abstract
BACKGROUND A high proportion of HIV patients in India are having pulmonary tuberculosis. The combined therapy of both HIV + PTB causes many unwanted side effects. The following study mainly aimed to study the impaired glucose metabolism in those patients. The aim of the study is to determine the incidence of disorders of glucose metabolism in HIV-1 infected tuberculosis adult on antiretroviral therapy (ART) and antituberculosis therapy (ATT) admitted in tertiary health centre in Guntur, Andhra Pradesh, India. MATERIALS AND METHODS This is two-year observational, analytical, prospective cohort study using data of all the HIV + PTB co-infected people admitted in tertiary health centre from March 2015 to March 2017. HIV infected ART naive tuberculosis patients eligible for ATT and ART (HIV-ART + ATT, n= 75) are included in the study. All participants had demographic, anthropometric, biochemical and radiological assessments at baseline; in addition, the HIV-ART group had follow-up assessments for 24 months on ART. Disorders of glucose metabolism namely diabetes mellitus (DM), impaired glucose tolerance and impaired fasting glucose were defined using WHO criteria at baseline 3, 6, 12, 18 and 24 months. Poisson approximations estimated incidence of disorders of glycaemia. Study Design- The study was a prospective, observational, analytical cohort study for two years among HIV and PTB co-infected patients. RESULTS At baseline, the prevalence of DM was 0% in HIV-ART + ATT patients. During the follow-up using glucose-based WHO criteria, 5 patients developed DM during 150.2 person-years with an incidence rate of 3.3 cases per 100 PYFU (95%, CI 0.6 - 5.1). 8 participants developed IGT during 156.1 PYFU with an incidence of 5.1 cases per 100 PYFU [95%, CI 3.5 - 6.2]) and 5 participants developed IFG during 141.5 PYFU with an incidence of 3.5 cases per 100 PYFU [95%, CI 1.4 - 4.6]). CONCLUSION ART was associated with increased incidence of impaired glucose metabolism. These findings underscore the importance of clinical monitoring of patients on ART and ATT.
Authors and Affiliations
Kalyan Kumar P. V, Ramakrishna Gorantla
Keywords
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- EP ID EP279319
- DOI 10.14260/jemds/2017/1438
- Views 88
- Downloads 0
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