Inflammation Driven Activation of Wnt Pathway: A Potential Mechanism Responsible for Obesity-associated Colorectal Cancer
Journal Title: Obesity Research - Open Journal - Year 2015, Vol 1, Issue 1
Abstract
Substantial evidence indicates that obesity, which has reached an epidemic proportion, is a robust risk factor for several types of cancer, particularly the colorectal cancer. As the worldwide obesity epidemic has shown no sign to decrease, whereas further increases in the scope of this problem are still projected, insight into the mechanisms of obesity-associated tumorignesis is urgently needed for the development of preventive approaches to block this process. Obesity is associated with multiple metabolic changes, and therefore a single mechanism is unlikely to be responsible for all obesity-associated tumors. A quite number of articles provided systemic reviews of the possible mechanisms for the association between obesity and the initiation and progression of cancers. In this mini-review, we focus on how obesity mediates colorectal cancer via inflammation driven Wnt-signaling pathway.
Authors and Affiliations
Zhenhua Liu
Keywords
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- EP ID EP561321
- DOI 10.17140/OROJ-1-103
- Views 125
- Downloads 0
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