Influence of combined oral contraceptive pills on the state of ovarian follicles and endometrium
Journal Title: Ginekologia i Położnictwo medical project - Year 2017, Vol 4, Issue 46
Abstract
Introduction. Oral contraceptive pills are based on two fundamental compositional formulas: pills with estrogens and progestins as well as pills with progestins alone. The study was conducted to evaluate ovarian function during the use of oral contraception by comparing 5 products differing in the dose of ethinyloestradiol (EE) and the type of progestin. Material and methods. It was a single-center, open-label, comparative study conducted in 89 healthy women divided into five groups: group 1: 0.03 mg of EE + 0.075 mg of gestodene (GSD), group 2: 0.03 mg of EE + 0.15 mg desogestrel (DGS), group 3: 0.02 mg of EE + 0.15 mg of DGS, group 4: 0.035 mg of EE + 0.25 mg of norgestimate (NGS), group 5: a triphasic preparation with 0.03–0.04 mg of EE + 0.05–0.125 mg of levonorgestrel (LNG). The 21+7 regimen was followed. On days 1–2 and 20–21 of the cycle, the number and diameter of ovarian follicles as well as endometrial thickness were measured with ultrasound. Moreover, estradiol and FSH concentrations were determined. Results. There were no significant differences in estradiol levels between the groups. However, the mean FSH level on day 20–21 of the cycle in group 4 was significantly higher (p = 0.006) than the mean levels observed in groups 1, 2 and 5. The greatest number of ovarian follicles was found in group 5 (16.4), and the lowest in group 3 (12.6), but these differences were not statistically significant. Moreover, differences were also noticed in the diameter of follicles on day 1–2. The mean value in group 5 (4.6 mm) was significantly higher than in the remaining groups: 3.6 mm, 3.4 mm, 3.3 mm and 3.4 mm, respectively. The endometrium on day 20–21 of the cycle was the thickest in group 5 (7.2 mm) and was significantly thicker than in all the remaining groups (p = 0.000005). Conclusions. All the tested products prevented ovulation in an effective way when used correctly. However, the level of follicular suppression and endometrial growth differed across the groups. Combined triphasic oral contraceptive pills with 30–40 µg of EE and 50–125 µg of LNG were characterized by lower suppressive capability than the products with lower EE doses. It can be suspected that the level of follicular suppression does not depend only on the EE dose, but also on the type of progestin, but the precise mechanism underlying this phenomenon remains unclear
Authors and Affiliations
Zbigniew Szymoniak, Martyna Siąkowska, Agnieszka Mitkowska, Robert Zawrotniak, Marcin Korman, Mateusz Trzciński, Leszek Pawelczyk, Beata Banaszewska
Keywords
Related Articles
- EP ID EP554965
- DOI -
- Views 163
- Downloads 0
Clinical usefulness of HE4 in pathologies other than ovarian carcinoma. A literature review
HE4 is a glycoprotein broadly used as a tumor marker in ovarian carcinoma. This article presents a literature review on the clinical usefulness of HE4 concentrations in the diagnosis and treatment of diseases other than...
Ocena stężeń białka HE4 u zdrowych kobiet ciężarnych oraz ciężarnych ze stanem przedrzucawkowym – badania pilotażowe
Cel. Celem głównym pracy była ocena stężeń białka HE4 u zdrowych kobiet ciężarnych w III trymestrze ciąży oraz bezpośrednio po porodzie, a także u ciężarnych i rodzących ze stanem przedrzucawkowym (PE) w analogicznym wie...
Aktywność fizyczna kobiet w ciąży – przegląd piśmiennictwa i aktualnych rekomendacji
Kobiety podejmujące aktywność fizyczną często rezygnują z niej w trakcie ciąży z obawy o zdrowie dziecka. Udowodniono korzystny wpływ ruchu w prewencji wielu chorób, co dotyczy także kobiet ciężarnych. Ćwiczenia fizyczne...
Von Willebrand disease from the viewpoint of obstetrician – case studies
Von Willebrand disease is the most common plasma hemorrhagic diathesis and at the same time one of the most common coagulation abnormality of non-obstetric origin encountered during pregnancies. The work describes the ca...
Rola bisfenolu A w endometriozie
Endometrioza stanowi schorzenie o niejednorodnej etiologii, w którym dochodzi do tworzenia się ognisk endometrium poza jamą macicy. Choroba najczęściej dotyczy kobiet w wieku rozrodczym. Obecnie, uznaje się, że istnieje...