Influence of Some Food Additives “Cocktail Effect” on White Rats Behavioural Parameters
Journal Title: The 1st Annual Meeting of Georgian Center for Neuroscience Research - Year 2020, Vol 2, Issue 20
Abstract
Food additives play an important role in preserving freshness, safety, taste, appearance and texture of processed foods. We know that some food additives could have bad influence individually. Today, young generation spend their most time in schools, where they eat in canteens. They buy products which consist a lot of feed additives. These products contain several food additives at the same time. The literature isn’t rich with information about the effect of mixed food additives influence on animals behavior. We used food, that love children: sausages, chips (Lux) and yellow and red sweets (M&M) which consist different kind of additives (E102, E104, E110, E122, E124, E129, E211, E250, E407, E450, E451, E621, E627 and E631). So, the aim of our experiments was to study the influence of the food additives’ “cocktail effect” on the animals’ behavior. Male wild 2,5-month-old 20 rats (150 –200 g) were housed in cages with water and food ad libitum, under controlled conditions of temperature and light/dark cycle. The experiments were conducted according with the legal and statutory acts applicable in Georgia and international agreements ratified by the country. For conducting behavioral experiments, animals were divided into two groups: testing (10 rats) and control (10 rats) groups. The animals of the testing group were fed as ordinary food, also foods with food additives. Control animals were fed only normal rat foods. The open field, T-maze and passive avoidance tests were carried out to assess emotional state, fear level, defensive reactions and memory/learning ability of animals. The results of experiments revealed that the testing group animals in the "open field" trial were not able to adapt to the new environment due to their dietary supplements, and the investigated activity remained high until the end of the trial. Spatial memory was damaged because of hyperactivity and attention deficit disorder. Genetically determined defensive behavior (passive avoidance reactions) also deteriorated and rats could no longer remember the dangerous place in the test room. Presumably, the "cocktail" of food additives in the nervous system increase the excitability, that causes the deficit of attention and hyperactivity of testing group animals. These changes have caused behavioural parameters disorders in testing group animals.
Authors and Affiliations
Ekatherine Mitaishvili and Otari Gokhadze
Keywords
Related Articles
- EP ID EP677950
- DOI 10.29088/GCNR-2020.41
- Views 179
- Downloads 0
The Impact of Neurofeedback Training on Anxiety Reduction: A Case Study on a Retired Elite Powerlifting Athlete
Background and Aim: Retirement is a stressful situation that most employed persons may experiencing that. Career termination among elite athletes can produce more pressure on them, because they experience this situation...
Investigating the Relationship Between Impulsivity and Deficit in Executive Functions of Brain in Patients with Substance Use Disorder
Introduction: In recent years, research into the biological foundations of addiction has attracted the attention of many researchers. Researchers found that substance use is the result of greater activity of the brain b...
Beneficial Effects of Japanese Sake Yeast Supplement on Depressive-Like Behaviors in a Rat Model of Global Cerebral Ischemia/Reperfusion
Background: Stroke is known to be one of the most frequent causes of mortality, responsible for high rates of death and disability around the world. Antioxidant agents can reduce ischemic nerve damage by eliminating fre...
Influence of Quercetin/Quercetin-Loaded Magnetic Nanoparticles on the Firing Patterns of Hippocampal Neurons in Control and Kainic Acid-Injected Rats
Epilepsy is one of the most common brain disorders. Regular treatment with the antiepileptic drugs is useful for controlling disease. However, more than 35% of people experience a resistant form. Development of epilepsy...
Glial Glutamate Transporter (GLT-1) Role in Dependence in Male Morphine-Treated Rats
Addiction as a neuropsychiatric disorder affects a large number of people and imposes a high economic burden on the community. Similar to other diseases, a proper understanding of the biological basis of addiction will...