Insulin Toujeo® — a Novel Basal Long-Acting Insulin Formulation Part 2. Clinical Efficacy and Safety
Journal Title: Міжнародний ендокринологічний журнал - Year 2015, Vol 8, Issue 72
Abstract
This review, consisting of two parts, considers a new formulation of insulin glargine (rDNA origin) in the form of injections 300 U/ml (Gla-300, Toujeo®). Gla-300 is a next generation basal insulin with a novel formulation of insulin glargin delivering the same amount of insulin, as glargine-100 (Gla-100) in 1/3 volume. Following the subcutaneous injection, pharmacokinetic and pharmacodynamic profiles of Gla-300 are more constant and prolonged (beyond 24 hours) compared with Gla-100 due to a more gradual and extended release of glargine from subcutaneous depot (Gla-300 forms a more compact subcutaneous depot with reduced surface area compared to Gla-100). The clinical efficacy and safety of Gla-300 in patients with type 1 and type 2 diabetes mellitus are discussed with an emphasis on recently released data from EDITION (the phase 3a) clinical trials. Gla-300 showed comparable glycaemic control and similar safety profile with lower incidence of hypoglycaemia events compared with Gla-100. Gla-300 provided flexible dosing of insulin (24 ± 3 h or morning vs evening) and was associated with less body weight gain.
Authors and Affiliations
V. V. Poltorak, N. А. Kravchun, M. Yu. Gorshunska
Keywords
Related Articles
- EP ID EP215624
- DOI -
- Views 81
- Downloads 0
Comparative characteristics of proteolytic activity in case of experimental peritonitis and its development on the background of diabetes mellitus
Background. The relevance is due to rather understudied state of proteolytic reactions in case of diabetes mellitus (DM) with acute peritonitis (AP), which is increasingly common in the practice. Objective: to study the...
Allergenspecific Immunotherapy: History, Current Views and Problems
As you know, the most common form of allergic reactions is the so-called IgE-mediated hypersensitivity, which, according to various authors, occurs in 25 % of the population of industrialized countries [1]. It is commonl...
Safety and Efficacy of Hypoglycemic Therapy: Place of Metformin
This review describes results of some basic large clinical trials on glucose lowering therapy directed on a prevention of macro- and microvascular complications of diabetes mellitus type 2. Authors emphasize that the res...
Constitutional delay of growth and puberty in boys: review
The review focuses on the diagnosis, clinical and general therapeutic approach to constitutional growth and delayed puberty and hypogonadotrophic hypogonadism in men, which are difficult to distinguish. Clinical history...
The Early Diagnosis of Hypothyroidism as a Factor in the Progression of Osteoarthritis and Comorbid Processes, the Features of Phytocorrection
Objective: to study the prevalence and forms of hypothyroidism in patients with osteoarthritis (OA) and to investigate the effect of phytomedication zobofit on the functional and morphological status of the thyroid gland...