Internal Quality control Monitoring & Evaluation of Creatinine, Urea, Alanine aminotransferase and Inter-Laboratory Assessment of Some Haematological Parameters In Two Hospitals in Central Nigeria.
Journal Title: IOSR Journal of Applied Chemistry (IOSR-JAC) - Year 2018, Vol 11, Issue 10
Abstract
The integrity of quality control samples is important to both management of overall quality as well as to meeting requirements of proficiency testing.The study was done to assess the quality control monitoring and evaluation of creatinine,urea,alanine aminotransferaseand also for inter-laboratory studies of somehaematological parameters packed cell volume (PCV),Mean cell Volume (MCV)andmean corpuscular haemoglobin (MCH), in Nisa Premier Hospital Abuja and the Benue State University Teaching Hospital Makurdi,North central Nigeria.The quality control monitoring& evaluation were conducted for two consecutive months using the spectrophotometer(kenza240 TXbiolabo France),and the inter -laboratory studies was performed directly on blood samples at both locations using the Automated Haematology Analyzer (KX-21N Sysmex, USA).The results of quality control assessment showed that Trends (loss of reliability) and shifts (abrupt changes in the control mean) were noted in the results of this study. The results of inter-laboratory assessment of the haematological parameters shows that both imprecision and bias exist between both laboratories. Although imprecision values were generally in the range of “Acceptable to marginal performance”, the overall bias between laboratories was in the range: SDI >1.5 or SDI < -1.5; In this study, Warning signs were recorded but there was no cause for rejection of the analytical run exception of alanine aminotransferase.
Authors and Affiliations
Stephen I. Audu, Isah Jibrin, Maryam Jibrin S. , J. Mohammed, Martha E. Ogbole
Keywords
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- EP ID EP414410
- DOI 10.9790/5736-1110010105.
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