Intra-operative squash cytology in diagnosing intracranial tumours- a useful method in resource-limited setting with lack of frozen section facility
Journal Title: Medpulse International Journal of Pathology - Year 2017, Vol 4, Issue 3
Abstract
Background: Neurosurgical practice frequently requires intraoperative consultation to optimize surgical procedure. Frozen section and Squash smear cytology can offer the same. As brain tissue is friable and predisposed to show ice crystal artefacts, frozen section is often difficult to interpret. Squash smear examination provides good cytological details to offer diagnosis in most cases except where anatomical correlation is needed. Aim: To evaluate the value of Squash smear cytology for rapid intraoperative diagnosis in CNS tumours. Materials and Methods: The study has been conducted for a period of two years from August 2014-July 2016. Total 36 patients with various intracranial lesions were enrolled in the study. Patients underwent various radio-imaging techniques and routine blood investigations. Later on, intra-operative squash cytology was performed and rapid diagnosis was made. Results: Of 36 cases, 88.9% (32 cases) were malignant and 11.1% (4 cases) were benign on squash cytology. Amongst malignant, gliomas were the most common constituiting to 15cases (41.7%). Other tumours which were studied are pilocyticastrocytoma, oligodendroglioma, schwannoma, lymphoma, medulloblastoma and ependymoma. Overall diagnostic Accuracy of squash was 95.25%. We were able to inform about the diagnosis to neurosurgeon in 15 minutes in all cases and within 12 minutes in >85% cases. Conclusion: Squash smear cytology is reliable, cost-effective, reproducible and rapid standalone diagnostic method and it can assist for intra-operative decision-making diagnosis of intracranial lesions in resource-limited settings where frozen section facility is not available.
Authors and Affiliations
Prachi 1, Sreelekha B V
Keywords
Related Articles
- EP ID EP260211
- DOI -
- Views 95
- Downloads 0
Assessment of the knowledge of blood transfusion among nursing staff: before and after implementing a designed teaching session about blood transfusion
Background: Blood is a precious resource that needs to be prescribed, handled, stored and transfused as per guidelines to ensure recipient safety. The present study aims to assess the basic knowledge of nurses pertaining...
Cyto-histopathological spectrum of palpable breast lesions presenting in rural based medical college and hospital at Warudi, Jalna (Maharashtra) India
Benign as well as malignant breast lesions are quite common in Indian population. Breast is second most common cancer site after cancer cervix in Indian females. Currently, 75,000 new cases of breast cancer are detected...
Knowledge, attitude and practices regarding voluntary blood donation
Background: The availability of safe and good quality blood is crucial in improving medical facilities in a society. A study on the KAP of the donors may prove to be useful in the successful implementation of the blood d...
Can Platelet count helps in suspecting malaria infection?: Data analysis from tertiary care hospital
Background: Onset of Malarial infection frequently presents with non specific symptoms and may resembles with other type of fever of other origin. Malaria is major health problem in India. It usually presents with hromb...
Evaluation of concordance between the cytological grading and histomorphological grading of breast carcinoma in a series of 100 cases
Background: Breast cancer survival is linked to early detection with timely appropriate treatment. Fine needle aspiration cytology is a reliable method for the initial evaluation and diagnosis of alpable masses of the br...