Investigating the Prevalence of Hepatitis Delta and Assessment of Treatment Response

Journal Title: Viral Hepatitis Journal - Year 2020, Vol 26, Issue 3

Abstract

Objectives: The purpose of this study was to investigate the seroprevalence of delta virus, assess the treatment outcomes of patients receiving treatment. Materials and Methods: The files of patients diagnosed with chronic hepatitis B followed up between 01.01.2015 and 31.12.2019 were examined. For the patients positive for delta antibody, demographic information, hepatitis delta virus (HDV)-RNA levels, treatment information and treatment outcomes were recorded from the files. Undetectable HDV-RNA levels after treatment was considered as total virologic response. Results: There was a delta antibody positivity in 2.9% (n=74) of the 2,548 patients positive for hepatitis B surface antigen (HBsAg). The HDV-RNA tests of 60 patients found to be positive for delta antibody could be accessed. HDV-RNA was positive in 33.3% (n=20/60) of these patients, while 60% among the positive ones (n=12) received treatment. Among the patients who received treatment, 58.3% (n=7) were male, 41.7% (n=5) were female, and their median age was 53 (31-69) years. There was virologic response in 50% of the patients who received treatment, while no patient displayed HBsAg seroclearance. Conclusion: At similar rates to those in other studies conducted in Turkey, hepatitis delta seroprevalence, virologic response rate were found to be low.

Authors and Affiliations

Pınar Ergen, Fatma Yılmaz Karadağ, Özlem Aydın

Keywords

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  • EP ID EP691651
  • DOI 10.4274/vhd.galenos.2020.2020.0025
  • Views 112
  • Downloads 0

How To Cite

Pınar Ergen, Fatma Yılmaz Karadağ, Özlem Aydın (2020). Investigating the Prevalence of Hepatitis Delta and Assessment of Treatment Response. Viral Hepatitis Journal, 26(3), -. https://europub.co.uk./articles/-A-691651