INVESTIGATION OF THE EFFECT OF FORMULATION ADDITIVES ON TELMISARTAN DISSOLUTION RATE: DEVELOPMENT OF ORAL DISINTEGRATING TABLETS
Journal Title: European Journal of Biomedical and Pharmaceutical Sciences - Year 2019, Vol 6, Issue 4
Abstract
The aim of this work was to enhance solubility of telmisartan by the preparation of amorphous solid dispersion in presence and absence of pH modifying agent. This was achieved by preparing solid dispersion (SD) of telmisaratin with a hydrophilic polymer (polyethylene glycol 4000), in presence and absence of meglumine. The latter was used as alkanizer. Binary solid dispersion was prepared by solvent evaporation technique at different drug:polymer weight ratios. To selected formulation, meglumine was included as third component at different molar ratios to obtain ternary mixtures. The obtained microparticles were evaluated using differential scanning calorimetry (DSC), Foriur Transform Infrared (FTIR), X-ray powder diffraction and in vitro drug release studies. Binary solid dispersion slightly improved drug dissolution over unprocessed drug. The optimum SD combination was formulated into oral disintegrating tablets using different ODT bases namely Pearlitol® Flash, Pharmaburst ® 500 and Ludiflash®. Incorporation of meglumine markedly increased telmisartan dissolution with about 80% of the loaded dose librated after 5 minutes. Physical characterization indicated compatibility between ingredients and reduced drug crystallinity. The optimum formulation was sucessfully used to prepare orodispersible tablets, with those prepared using Pharmaburst ® 500 as filler showed optimum tablets quality and drug release pattern, compared to other fillers.
Authors and Affiliations
Maysa A. Hussien
Keywords
Related Articles
- EP ID EP670608
- DOI -
- Views 152
- Downloads 0
SPECTROPHOTOMETRIC DETERMINATION OF VITAMIN E VIA FORMATION OF GOLD COMPLEX
Two different methods were used for the determination of vitamin E (Tocopherol) via complex formation with gold ions in solutions using UV - VIS spectrophotometry and flame atomic absorption spectrophotometry (AAS). The...
EUGENOL AMELIORATES LETROZOLE INDUCED POLYCYSTIC OVARY SYNDROME IN RATS
Background: It is now evident that there is a strong association between oxidative stress and chronic low grade inflammation in polycystic ovary syndrome (PCOS) pathogenesis. Therefore, simultaneous targeting of these pa...
A COMPARATIVE STUDY ON ANTI DIABETIC ACTIVITY OF CRUDE EXTRACTS OF ENDOPHYTIC FUNGI FROM SEA WEED GRACILARIA CORTICATA
Diabetes, often referred to by doctors as Diabetes mellitus, describes a group of metabolic diseases in which the person has high blood glucose (blood sugar).Insulin is a hormone that is produced by the pancreas.. Inhibi...
EVALUATION OF TOTAL CHOLESTEROL & GLUCOSE LEVELS AMONG SUDANESE WOMEN WITH PREECLAMPSIA
Background:- Preeclampsia is a serious problem for many as one in 12 women during pregnancy. It generally occurs after 20th week and is marked by increase blood pressure, serum cholesterol and protein in the urine. Metho...
AMELIORATION EFFECT ON DIABETES BY ETHYL ACETATE AND METHANOL LEAF FRACTIONS OF Nauclea Latifolia IN ALLOXAN-INDUCED DIABETIC RATS
The antidiabetic effects of ethyl acetate and methanol fractions of Nauclea latifolia were investigated in alloxan induced diabetic rats. Fractions of Nauclea latifolia at the doses of 150 and 300mg/kg were administered...