Investigation of variants of critically important antioxidant enzyme genes in patients with polycystic ovary syndrome
Journal Title: UNKNOWN - Year 2019, Vol 2, Issue 1
Abstract
Aim: To investigate the possible effects of polymorphisms in genes encoding some important antioxidant enzymes such as super oxide dismutase 2 (SOD2), glutathione peroxidase 1 (GPX1), endothelial NOS (eNOS) and catalase (CAT) in patients with polycystic ovary syndrome (PCOS). Methods: Peripheral blood of 100 patients with PCOS and 100 healthy control group were collected, Polymorphisms in related genes was investigated by using polymerase chain reaction-restriction fragment length polymorphism. In addition, the related biochemical values of the patients were also investigated. Result: In our study there is no significant results for SOD2 gene but the results obtained between GPX1, eNOS and CAT genes were significant. Fasting blood sugar (FBS), insulin, triglyceride, waist circumference and dehydroepiandrosterone sulphate (DHEAS) were found to be significant with the disease, whereas follicle-stimulating hormone (FSH) was found to be effective in preventing the disease. Conclusions: These findings suggest that polymorphisms in genes encoding GPX1, eNOS and CAT enzymes may be associated with PCOS. Additionally, it is thought that the genes of FBS, triglyceride, insulin, DHEAS and waist circumference are important in the pathogenesis of the disease in the presence of homozygous mutation.
Authors and Affiliations
Ali Osman Arslan, Faruk Celik, Ozlem Kucukhuseyin, Bulent Duran, Murat Diramali, Sakir Umit Zeybek, Selma Duzenli, Ilhan Yaylim
Keywords
Related Articles
- EP ID EP488253
- DOI 10.30714/j-ebr.2019147578
- Views 147
- Downloads 0
The relation between antiepileptic drug type and cognitive functions in childhood epilepsy: A prospective observational study
Aim: This study investigated the effect of antiepileptic drug monotherapy on cognitive functions in pediatric epilepsy patients. Methods: 98 recently diagnosed epilepsy patients aged 6-16 years were included. All pat...
Evaluation of the resistance patterns of Mycobacterium tuberculosis complex strains to antituberculous drugs
Aim: To determine the resistance profile of Mycobacterium tuberculosis complex (MTBC) strains to first-line antituberculous drugs. Methods: A total of 138 patients with MTBC growth from 2008-2018 were evaluated retrospec...
Can gestational exercise have a positive effect on cognitive functions resulting from brain injury? A rat study
Aim: The effects of gestational exercise on potential pathological conditions is not known yet. Therefore, in the present study, it was aimed to evaluate the effects of forced running exercise on lipopolysa...
Patients’ misperception regarding the difficulty of lumbar puncture
Aim: Lumbar puncture (LP) is a crucial method of diagnosis and treatment of neurological diseases. Despite its importance, the patients' refusal of the procedure leads to difficulties in diagnosis and treatment. One of t...
Obesity is associated with lower levels of vitamin D
Aim: In this study we aimed to compare the 25(OH) vitamin D level of obese patients and the serum 25(OH) vitamin D level of healthy individuals who have normal weight; and also to evaluate the relation between 25(OH)...