Invitro And Insilico Anticancer Activity Of Murraya Koenigii (L) Against Breast Cancer
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2018, Vol 13, Issue 5
Abstract
Phytochemical screening study well showed the presence of alkaloids, steroids, protein, saponins and flavonoids. Murraya koenigii leaves have potent antioxidant. Murraya koenigii leaves possess anticancer activity against MCF- 7 cell lines, like wise Murraya koenigii leaves possess antibacterial agent against Pseudomonas aeruginosa, Bacillus subtilis and Escherichia coli. Docking studies were performed for the four proteins with four marker compounds. The interaction of protein and ligands for the docked ligands with least binding energy was calculated. Mahanimbicine has least binding energy with HER2 protein. Further research has to be conducted for components present in the methanolic extract of Murraya koenigii which may act as active principles. In future the components present on Murraya koenigii may act as a drug, for the above mentioned cell line.
Authors and Affiliations
Shabnashmi P. S. , Senthilmanickam J. , Gopinath L. R, Archaya . S
Keywords
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- EP ID EP415652
- DOI 10.9790/3008-1305038287.
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