KARYOMETRIC ANALYSIS OF SQUAMOUS METAPLASIA, DYSPLASIA AND SQUAMOUS CELL CARCINOMA OF THE LUNG
Journal Title: Acta Facultatis Medicae Naissensis - Year 2014, Vol 31, Issue 3
Abstract
The sequence of precursor lesions for squamous cell carcinoma may be hyperplasia-metaplasia-dysplasia-carcinoma in situ. The aim of this study was to perform a karyometric analysis of squamous metaplasia, moderate dysplasia and squamous cell lung carcinoma. Bronchoscopic biopsies of normal mucosa in chronic bronchitis patients (n=10), squamous metaplasia (n=10), moderate dysplasia (n=11), squamous cell lung carcinoma (n=48), and normal appearing mucosa surrounding carcinoma (n=11) were retrieved. Three nuclear variables were estimated using an image analysis system. The mean equivalent diameter, nuclear area and volume of equivalent sphere of squamous cell lung carcinoma were significantly larger than in moderate dysplasia, squamous metaplasia and normal bronchial mucosa. Also, the values of equivalent diameter, nuclear area and volume of equivalent sphere were significantly larger in normal appearing mucosa surrounding carcinoma compared to normal mucosa in chronic bronchitis patients. Karyometric analysis may be a helpful ancillary tool in distinguishing squamous cell lung carcinoma from dysplasia, and dysplasia from squamous metaplasia in bronchoscopic biopsy specimens.
Authors and Affiliations
Žaklina Mijović, Zoran Pešić, Nikola Živković, Tijana Denčić, Ana Ristić Petrović, Slavica Stojnev
Keywords
Related Articles
- EP ID EP147688
- DOI 10.2478/afmnai-2014-0022
- Views 104
- Downloads 0
Prikaz bolesnice nakon korektivne hirurgije tetralogije Falot
Prikazana je bolesnica stara 25 godina sa tetralogijom Fallot. Ova urođena srčana mana nije tako česta, ali je najčešća među manama sa cijanozom. Lečenje bolesnica sa tetralogijom Fallot je hirurško i može biti palijat...
PREOPERATIVNA PRIPREMA BOLESNICA ZA GINEKOLOŠKE OPERACIJE
Za operativno lečenje bolesnice obolele od ginekološke bolesti odlučujmo se nakon što su iscrpljene sve mogućnosti konzervativnog lečenja. Operativno lečenje predstavlja stres za bolesnicu, a rizici i komplikacije koje o...
POVEZANOST ANATOMSKIH VARIJACIJA SINONAZALNE REGIJE SA HRONIČNIM RINOSINUZITISOM: PROSPEKTIVNA STUDIJA
Hronični rinosinuzitis je hronična upala nazalnih i paranazalnih šupljina. Međutim, osnovna patofiziologija ovih hroničnih stanja je nedovoljno opisana i zaivisi od više faktora. U studiji koju smo sproveli pregledali sm...
A Rare Case of Primary Breast Mucosa-Associated Lymphoid Tissue Lymphoma - - - Redak slučaj primarnog MALT limfoma dojke
Breast involvement by lymphoma is uncommon and poses challenges in diagnosis. Breast involvement by malignant lymphoma, whether primary or secondary, is a rare event. Primary breast lymphomas account for 0.38% – 0.7% of...
NOVIJI PROGNOSTIČKI MARKERI TEŠKE VANBOLNIČKI STEČENE PNEUMONIJE
Vanbolnički stečena pneumonija (VSP) je i dalje vodeći uzrok smrtnosti među infektivnim bolestima. Tokom lečenja bolesnika sa pneumonijom često je neizvesno kada bolest može prerasti u tešku pneumoniju. Termin „teška pne...